About: CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS

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About: CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Poster presenting clinical utility of molecular characterization of gastric cancer. According to the Czech national cancer register the prognosis of gastric cancer patients has remained unchanged over the course of the past 20 years. With a 5-year survival of just 30% (for all stages) it is the third most fatal malignancy of the gastrointestinal tract and sixth overall among solid cancers. The recent trends in discovery and use of biomarkers in other cancers have been mainly derived from detailed tumor profiling. Somatic mutations and gene amplifications are among the molecular aberations frequently studied. The conclusion is: Somatic mutations are not associated with localization or stage and are likely not factors in prognosis of the disease. Molecular classification of gastric cancer based on gene amplification patterns results in distinct tumor similarities that may have clinical relevance for clinical management of gastric cancer. Poster presenting clinical utility of molecular characterization of gastric cancer. According to the Czech national cancer register the prognosis of gastric cancer patients has remained unchanged over the course of the past 20 years. With a 5-year survival of just 30% (for all stages) it is the third most fatal malignancy of the gastrointestinal tract and sixth overall among solid cancers. The recent trends in discovery and use of biomarkers in other cancers have been mainly derived from detailed tumor profiling. Somatic mutations and gene amplifications are among the molecular aberations frequently studied. The conclusion is: Somatic mutations are not associated with localization or stage and are likely not factors in prognosis of the disease. Molecular classification of gastric cancer based on gene amplification patterns results in distinct tumor similarities that may have clinical relevance for clinical management of gastric cancer. (en)
Title	CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS (en)
skos:prefLabel	CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS (en)
skos:notation	RIV/26475821:_____/13:#0000191!RIV14-MZ0-26475821
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13640)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Minárik, Marek Benešová, Lucie Belšánová, Barbora
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Genomac International, s.r.o.
http://linked.open...dnocenehoVysledku	65708
http://linked.open...ai/riv/idVysledku	RIV/26475821:_____/13:#0000191
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	APC, CTNNB1, KRAS, BRAF, EGFR, PIK3CA, TP53 (en)
http://linked.open.../riv/klicoveSlovo	EGFR KRAS CTNNB1 TP53 PIK3CA APC BRAF
http://linked.open...ontrolniKodProRIV	[BFC94A3E3B0A]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Applicability of a panel of molecular markers in clinical management of advanced gastric cancer
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Belšánová, Barbora Benešová, Lucie Minárik, Marek

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