About: The Role of Specific KRAS Mutation Types in Response to Treatment by EGFR Inhibitors.

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About: The Role of Specific KRAS Mutation Types in Response to Treatment by EGFR Inhibitors. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	KRAS mutations can be found in 15 to 25% of lung cancers, frequently in adenocarcinomas and their presence is associated with smoking. The role of KRAS mutations in biological targeted therapy by EGFR inhibitors is ambiguous. While some reports clearly assigned mutated KRAS as negative prognostic factor and negative predictor, others did not confirm such notion. In our work we aimed to elucidate the role of specific type of KRAS mutation in outcome of patients with advanced NSCLC threated with EGFR-TKI therapy. KRAS mutations can be found in 15 to 25% of lung cancers, frequently in adenocarcinomas and their presence is associated with smoking. The role of KRAS mutations in biological targeted therapy by EGFR inhibitors is ambiguous. While some reports clearly assigned mutated KRAS as negative prognostic factor and negative predictor, others did not confirm such notion. In our work we aimed to elucidate the role of specific type of KRAS mutation in outcome of patients with advanced NSCLC threated with EGFR-TKI therapy. (en)
Title	The Role of Specific KRAS Mutation Types in Response to Treatment by EGFR Inhibitors. The Role of Specific KRAS Mutation Types in Response to Treatment by EGFR Inhibitors. (en)
skos:prefLabel	The Role of Specific KRAS Mutation Types in Response to Treatment by EGFR Inhibitors. The Role of Specific KRAS Mutation Types in Response to Treatment by EGFR Inhibitors. (en)
skos:notation	RIV/26475821:_____/11:#0000125!RIV12-MZ0-26475821
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS9718)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Minárik, Marek Benešová, Lucie Belšánová, Barbora
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Genomac International, s.r.o.
http://linked.open...dnocenehoVysledku	227509
http://linked.open...ai/riv/idVysledku	RIV/26475821:_____/11:#0000125
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	KRAS mutation; treatment; EGFR inhibitors (en)
http://linked.open.../riv/klicoveSlovo	KRAS mutation treatment EGFR inhibitors
http://linked.open...ontrolniKodProRIV	[959EF12D6FAF]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities for application of molecular-diagnostic methods for early detection and proper therapy selection of progressing Non-Small Cell Lung Cancer based on detection and monitoring of hypermethylation of specific genes
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Belšánová, Barbora Benšová, Lucie Minárik, Marek

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