About: FREQUENCY OF HYPERMETHYLATION OF SELECTED TUMOUR-SUPRESSOR GENES IN NSCLC AFTER STRATIFICATION ACCORDING TO HISTOLOGIC TYPES AND SMOKING STATUS

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About: FREQUENCY OF HYPERMETHYLATION OF SELECTED TUMOUR-SUPRESSOR GENES IN NSCLC AFTER STRATIFICATION ACCORDING TO HISTOLOGIC TYPES AND SMOKING STATUS Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Epigenetic changes, identified as methylations in tumour suppressor genes and histone modifications, are frequently found NSCLC lung tissue samples. According to recent reports, these changes may have certain diagnostic and prognostic value. Patients and methods: A group of 154 consecutive patients predominantly with stage III-IV NSCLC, who were treated by chemotherapy or therapy, was admitted into this study. Hypermethylation status of genes CHFR, CDH13, RARB, APC, RASSF1A, CDKN2A(p16) and MGMT was investigated in tumor-positive cytologic samples from bronchoscopic investigation a the beginning of the therapy. Epigenetic changes, identified as methylations in tumour suppressor genes and histone modifications, are frequently found NSCLC lung tissue samples. According to recent reports, these changes may have certain diagnostic and prognostic value. Patients and methods: A group of 154 consecutive patients predominantly with stage III-IV NSCLC, who were treated by chemotherapy or therapy, was admitted into this study. Hypermethylation status of genes CHFR, CDH13, RARB, APC, RASSF1A, CDKN2A(p16) and MGMT was investigated in tumor-positive cytologic samples from bronchoscopic investigation a the beginning of the therapy. (en)
Title	FREQUENCY OF HYPERMETHYLATION OF SELECTED TUMOUR-SUPRESSOR GENES IN NSCLC AFTER STRATIFICATION ACCORDING TO HISTOLOGIC TYPES AND SMOKING STATUS FREQUENCY OF HYPERMETHYLATION OF SELECTED TUMOUR-SUPRESSOR GENES IN NSCLC AFTER STRATIFICATION ACCORDING TO HISTOLOGIC TYPES AND SMOKING STATUS (en)
skos:prefLabel	FREQUENCY OF HYPERMETHYLATION OF SELECTED TUMOUR-SUPRESSOR GENES IN NSCLC AFTER STRATIFICATION ACCORDING TO HISTOLOGIC TYPES AND SMOKING STATUS FREQUENCY OF HYPERMETHYLATION OF SELECTED TUMOUR-SUPRESSOR GENES IN NSCLC AFTER STRATIFICATION ACCORDING TO HISTOLOGIC TYPES AND SMOKING STATUS (en)
skos:notation	RIV/26475821:_____/10:#0000096!RIV11-MZ0-26475821
http://linked.open...avai/riv/aktivita	O P
http://linked.open...avai/riv/aktivity	O, P(NS9718)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Meszárosová, Anna Minárik, Marek Kopečková, Marta Benešová, Lucie
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Genomac International, s.r.o.
http://linked.open...dnocenehoVysledku	259812
http://linked.open...ai/riv/idVysledku	RIV/26475821:_____/10:#0000096
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NSCLC; HYPERMETHYLATION; TUMOUR-SUPRESSOR GENES; SMOKING STATUS; HISTOLOGIC TYPES (en)
http://linked.open.../riv/klicoveSlovo	HYPERMETHYLATION NSCLC HISTOLOGIC TYPES SMOKING STATUS TUMOUR-SUPRESSOR GENES
http://linked.open...ontrolniKodProRIV	[699A4371D1C1]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities for application of molecular-diagnostic methods for early detection and proper therapy selection of progressing Non-Small Cell Lung Cancer based on detection and monitoring of hypermethylation of specific genes
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Benešová, Lucie Kopečková, Marta Minárik, Marek Pešek, Miloš Mészárosová, Anna

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