About: Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages     Goto   Sponge   NotDistinct   Permalink

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  • This study focused on the ability of diplacone to modulate the gene expression of pro-inflammatory tumour necrosis factor alfa and monocyte chemoattractant protein 1, and of anti-inflammatory zinc finger protein 36. In model, diplacone significantly down-regulated the expression of tumour necrosis factor alfa and monocyte chemoattractant protein 1 and up-regulated the zinc finger protein 36 expression. This makes diplacone a promising molecule for treatment of the inflammatory stage of diseases. The effect of diplacone in decreasing lipopolysaccharide-induced inflammatory gene expression is in many way similar to that of the drug indomethacin.
  • This study focused on the ability of diplacone to modulate the gene expression of pro-inflammatory tumour necrosis factor alfa and monocyte chemoattractant protein 1, and of anti-inflammatory zinc finger protein 36. In model, diplacone significantly down-regulated the expression of tumour necrosis factor alfa and monocyte chemoattractant protein 1 and up-regulated the zinc finger protein 36 expression. This makes diplacone a promising molecule for treatment of the inflammatory stage of diseases. The effect of diplacone in decreasing lipopolysaccharide-induced inflammatory gene expression is in many way similar to that of the drug indomethacin. (en)
Title
  • Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages
  • Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages (en)
skos:prefLabel
  • Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages
  • Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages (en)
skos:notation
  • RIV/26249308:_____/10:#0000007!RIV11-MPO-26249308
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(FT-TA5/025), S
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 255954
http://linked.open...ai/riv/idVysledku
  • RIV/26249308:_____/10:#0000007
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • geranyl flavanone; inflammation; MCP-1; mRNA; TNF-alfa; ZFP36 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [FF7E42447C6F]
http://linked.open...i/riv/nazevZdroje
  • Folia Biologica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 56
http://linked.open...iv/tvurceVysledku
  • Hošek, J.
  • Závalová, V.
  • Šmejkal, K.
  • Bartoš, Milan
issn
  • 0015-5500
number of pages
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