| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Verification of efficacy of Biocan B inj. ad us. vet. was done by challenge test. Ticks were used as vectors of infection. Formation of OspA specific antibodies and borrelia specific immunoglobulins was measured in canine sera. Tissues were used for detection of borreliae by cultivation method and DFM. Formation of IgG and OspA antibodies after vaccination was observed. Results are presented in the article. Development of new vaccine is based on preparation of recombinant outer surface proteins of B. afzelii, B. burgdorferi and B. garinii origin. Recombinant proteins were expressed in E. coli. Obtained proteins are being tested. Formation of specific antibodies against some recombinant proteins was confirmed. These proteins are suitable candidates for preparation of vaccine prototype and will be used in challenge tests.
- Verification of efficacy of Biocan B inj. ad us. vet. was done by challenge test. Ticks were used as vectors of infection. Formation of OspA specific antibodies and borrelia specific immunoglobulins was measured in canine sera. Tissues were used for detection of borreliae by cultivation method and DFM. Formation of IgG and OspA antibodies after vaccination was observed. Results are presented in the article. Development of new vaccine is based on preparation of recombinant outer surface proteins of B. afzelii, B. burgdorferi and B. garinii origin. Recombinant proteins were expressed in E. coli. Obtained proteins are being tested. Formation of specific antibodies against some recombinant proteins was confirmed. These proteins are suitable candidates for preparation of vaccine prototype and will be used in challenge tests. (en)
- Čelenží byla ověřena účinnost vakcíny Biocan B inj. ad us. vet. Jako vektor infekce byla použita klíšťata. V sérech psů byly stanovovány specifické protilátky outer surface proteinu A a specifické borreliové imunoglobuliny. Pro detekci borrelií kultivační metodou a DFM byly použity vzorky tkání. Byla sledována tvorba protilátek IgG a OspA po vakcinaci. Výsledky jsou prezentovány. Vývoj nové vakcíny spočívá v přípravě rekombinantních Osp původu B. afzelii, B. burgdorferi a B. garinii. Rekombinantní proteiny byly produkovány v E. coli. Získané proteiny jsou testovány na myších. Byla potvrzena tvorba specifických protilátek proti některým rekombinantním proteinům. Tyto proteiny jsou vhodnými kandidáty pro přípravu prototypu vakcíny a budou použity v čelenžních testech. (cs)
|
| Title
| - Testace vakcíny Biocan B inj. ad us. vet. a vývoj nové rekombinantní vakcíny proti borrelióze psů. (cs)
- Testing of the Biocan B inj. ad us. vet. vaccine and development of the new recombinant vaccine against canine borreliosis.
- Testing of the Biocan B inj. ad us. vet. vaccine and development of the new recombinant vaccine against canine borreliosis. (en)
|
| skos:prefLabel
| - Testace vakcíny Biocan B inj. ad us. vet. a vývoj nové rekombinantní vakcíny proti borrelióze psů. (cs)
- Testing of the Biocan B inj. ad us. vet. vaccine and development of the new recombinant vaccine against canine borreliosis.
- Testing of the Biocan B inj. ad us. vet. vaccine and development of the new recombinant vaccine against canine borreliosis. (en)
|
| skos:notation
| - RIV/25304046:_____/05:#0000001!RIV06-MPO-25304046
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/25304046:_____/05:#0000001
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - borrelia; challenge test; recombinant vaccine; OspA; OspC; Dog; Biocan B; BALB/c mice (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Weigl, Evžen
- Křupka, Michal
- Nepeřený, Jiří
- Vrzal, Vladimír
- Běláková, Jana
- Chumela, Josef
- Tuháčková, Jana
|
| issn
| |
| number of pages
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)