About: Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-alpha) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4-212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7-40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase-polymerase chain reaction [%22complete'' molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4-10) years, while 2 continue with IFN-alpha and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01-0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-alpha therapy and required imatinib, patients who achieved CMR had excellent long-term outcome. We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-alpha) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4-212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7-40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase-polymerase chain reaction [%22complete'' molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4-10) years, while 2 continue with IFN-alpha and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01-0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-alpha therapy and required imatinib, patients who achieved CMR had excellent long-term outcome. (en)
Title	Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia (en)
skos:prefLabel	Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia Operational cures after interferon-alpha in patients with chronic myeloid leukemia in Central and Northern Moravia (en)
skos:notation	RIV/00843989:_____/12:00103107!RIV13-MZ0-00843989
http://linked.open...avai/riv/aktivita	S V Z
http://linked.open...avai/riv/aktivity	S, V, Z(MSM6198959205), Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Matuška, Milan Gumulec, Jaromír Blahutová, Šárka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	156679
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/12:00103107
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chronic myelogenous leukemia; fusion gene transcripts; residual disease; responses; imatinib; cells (en)
http://linked.open.../riv/klicoveSlovo	responses cells chronic myelogenous leukemia imatinib fusion gene transcripts residual disease
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7713205F6660]
http://linked.open...i/riv/nazevZdroje	Journal of interferon & cytokine research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	58 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Faber, E. Gumulec, Jaromír Jarošová, M. Matuška, Milan Indrák, K. Zapletalová, J. Blahutová, Šárka Divoká, M. Holzerová, M. Kuba, A. Rohoň, P. Rožmanová, Š.
http://linked.open...ain/vavai/riv/wos	000304312600006
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů
issn	1079-9907
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1089/jir.2011.0108

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