About: A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept?

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept? Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Excessive forms of the response of an organism to infection play an important role in the pathogenesis of severe sepsis. They may consist of either a local pro-inflammatory response with the massive release of cytokines into the systemic circulation, or may be presented with an excessive systemic anti-inflammatory response. In the first case, the result is a systemic pro-inflammatory state, characterised by a natural stages of the inflammatory response in which dysfunction of macrocirculation is followed by microcirculation derangement and mitochondrial alteration at the end. These mechanisms are responsible for the development of remote organs failure. The result in the second case is a deactivation of local immunocompetent cells, which results in the risk of uncontrollable growth of microorganisms, especially in organs with impaired antimicrobial barrier. This may explain the clinically observed recurrence of septic episodes, when a resolution of infection on one site is later repla Excessive forms of the response of an organism to infection play an important role in the pathogenesis of severe sepsis. They may consist of either a local pro-inflammatory response with the massive release of cytokines into the systemic circulation, or may be presented with an excessive systemic anti-inflammatory response. In the first case, the result is a systemic pro-inflammatory state, characterised by a natural stages of the inflammatory response in which dysfunction of macrocirculation is followed by microcirculation derangement and mitochondrial alteration at the end. These mechanisms are responsible for the development of remote organs failure. The result in the second case is a deactivation of local immunocompetent cells, which results in the risk of uncontrollable growth of microorganisms, especially in organs with impaired antimicrobial barrier. This may explain the clinically observed recurrence of septic episodes, when a resolution of infection on one site is later repla (en)
Title	A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept? A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept? (en)
skos:prefLabel	A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept? A response to infection in patients with severe sepsis - do we need a Stage-Directed Therapy Concept? (en)
skos:notation	RIV/00843989:_____/09:00100617!RIV10-MZ0-00843989
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	no.8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	NEISER, Jan Szturz, Pavel Máca, Jan Kula, Roman Sklienka, Peter Chýlek, Václav Tichý, Jiří Sukeník, Pavol
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	301547
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/09:00100617
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	infection; inflammatory response; severe sepsis; therapeutic intervention (en)
http://linked.open.../riv/klicoveSlovo	infection inflammatory response severe sepsis therapeutic intervention
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[2B5B2F1148C3]
http://linked.open...i/riv/nazevZdroje	Bratislavské lekárske listy
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	110
http://linked.open...iv/tvurceVysledku	Neiser, Jan Chýlek, Václav Kula, Roman Máca, Jan Sklienka, Peter Sukeník, Pavol Szturz, Pavel Tichý, Jiří
http://linked.open...ain/vavai/riv/wos	000269177400003
issn	0006-9248
number of pages	6 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software