About: Autologous Bone Marrow Stem Cell Transplantation in Patients with End-Stage Chronical Critical Limb Ischemia and Diabetic Foot

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About: Autologous Bone Marrow Stem Cell Transplantation in Patients with End-Stage Chronical Critical Limb Ischemia and Diabetic Foot Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Summary: A total 37 patients suffering from end stage-IV Fontaine (CLI and diabetic foot) with an ulcerated limb in whom all previous thera- peutic strategies failed (e.g. surgical revascularization and endovascular repair) were selected and underwent local transplantation of Autolo- gous Bone Marrow Stem Cells (ABMSCs). The efficacy/safety of this therapy was assessed by using several endpoints such as (a) prevention of amputation, (b) wound healing and (c) degree of angiogenesis. In order to assess the limb ischemia and hypoxia the several tests and measure- ments were performed pre- and post transplantation at a variety of time intervals. The measurements include: TP-toe pressure measurements (by Periflux 5000 Laser Doppler and Oxymetry system), SPP-skin perfusion pressure, ABI-ankle brachial index, LDP-Laser Doppler baseline and heat perfusion assessment, TcpO2 without and with O2 provocation inhalation test. In addition, a battery of biochemical and hemato- logical tests of periph Summary: A total 37 patients suffering from end stage-IV Fontaine (CLI and diabetic foot) with an ulcerated limb in whom all previous thera- peutic strategies failed (e.g. surgical revascularization and endovascular repair) were selected and underwent local transplantation of Autolo- gous Bone Marrow Stem Cells (ABMSCs). The efficacy/safety of this therapy was assessed by using several endpoints such as (a) prevention of amputation, (b) wound healing and (c) degree of angiogenesis. In order to assess the limb ischemia and hypoxia the several tests and measure- ments were performed pre- and post transplantation at a variety of time intervals. The measurements include: TP-toe pressure measurements (by Periflux 5000 Laser Doppler and Oxymetry system), SPP-skin perfusion pressure, ABI-ankle brachial index, LDP-Laser Doppler baseline and heat perfusion assessment, TcpO2 without and with O2 provocation inhalation test. In addition, a battery of biochemical and hemato- logical tests of periph (en)
Title	Autologous Bone Marrow Stem Cell Transplantation in Patients with End-Stage Chronical Critical Limb Ischemia and Diabetic Foot Autologous Bone Marrow Stem Cell Transplantation in Patients with End-Stage Chronical Critical Limb Ischemia and Diabetic Foot (en)
skos:prefLabel	Autologous Bone Marrow Stem Cell Transplantation in Patients with End-Stage Chronical Critical Limb Ischemia and Diabetic Foot Autologous Bone Marrow Stem Cell Transplantation in Patients with End-Stage Chronical Critical Limb Ischemia and Diabetic Foot (en)
skos:notation	RIV/00843989:_____/09:00016075!RIV10-MZ0-00843989
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Klement, Petr Chmelová, Jana Czerný, Daniel Jonszta, Tomáš Procházka, Václav Krajča, Jan Gumulec, Jaromír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	304441
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/09:00016075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	critical limb ischemia; diabetic foot; bone marrow stem cells; transplantation (en)
http://linked.open.../riv/klicoveSlovo	critical limb ischemia transplantation bone marrow stem cells diabetic foot
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[4C6891E26B76]
http://linked.open...i/riv/nazevZdroje	Vnitřní lékařství
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Chmelová, Jana Gumulec, Jaromír Krajča, Jan Procházka, Václav Jonszta, Tomáš Czerný, Daniel Klement, Petr Klement, G. L.
issn	0042-773X
number of pages	6 (xsd:int)

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