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| Description
| - V publikovaných studiích, týkajících se karcinomu prostaty, se uvádí, že amplifikace genu c-myc je pevně spojena s imunohistochemickou overexpresí proteinu Myc. Existuje předpoklad, že nadměrná exprese proteinu Myc způsobuje degradaci proteinu p27 vedoucí k aktivaci dráhy cyklin E/cyclin-dependentní kinázy 2 a buněčné proliferaci. Jelikož je prokázáno , že s progresí karcinomu prostaty je spojeno mnoho chromozomálních a genetických abnormalit, bylo cílem naší studie prokázat, zda existuje vztah exprese proteinu p27 k těmto genetickým abnormitám.Protože nejčastěji postiženým chromozomem u karcinomu prostaty je chromozom 8 a nejčastějšími chromozomálními změnami jsou delece 8p22 a amplifikace oblasti 8q24, byly hodnoceny právě tyto změny. Naše ýsledky jsou plně v souladu s literárními údaji. Degradace proteinu p27 představovaná expresí 0-25% převládá u skupiny karcinomů s nálezem chromozomálních změn. U karcinomů s amplifikací genu c-myc je nález výrazně snížené exprese proteinu p (cs)
- Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch
- Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch (en)
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| Title
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| skos:prefLabel
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| skos:notation
| - RIV/00843989:_____/07:00015024!RIV09-MZ0-00843989
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00843989:_____/07:00015024
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - 8p22 loss; 8q24 amplification; prostate cancer; Gleason´s score; p27Kipl; prognosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dvořáčková, Jana
- Uvírová, M.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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