About: Procalcitonin - a marker and mediator of inflammation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Evaluation of procalcitonin levels is a sensitive investigation which is significant for differentiation between microbial and non-microbial infection, a determination of its dynamics and a prediction of therapy results. It is, however, necessary to evaluate its levels in relation to other investigations and their dynamics (other inflammatory markers, organ function dynamics), which specify diagnosis with the clinical condition of a patient. Even today, 10 years after the discovery of procalcitonin as an inflammatory marker and likely mediator of a cytokine cascade, there are many unanswered questions regarding its production in relation to physiological significance during the defensive response of an organism (12). Boucher formulated a simple conclusion in 2000: Procalcitonin should not be seen as the marker of sepsis but as one of many potentially useful markers. Evaluation of procalcitonin levels is a sensitive investigation which is significant for differentiation between microbial and non-microbial infection, a determination of its dynamics and a prediction of therapy results. It is, however, necessary to evaluate its levels in relation to other investigations and their dynamics (other inflammatory markers, organ function dynamics), which specify diagnosis with the clinical condition of a patient. Even today, 10 years after the discovery of procalcitonin as an inflammatory marker and likely mediator of a cytokine cascade, there are many unanswered questions regarding its production in relation to physiological significance during the defensive response of an organism (12). Boucher formulated a simple conclusion in 2000: Procalcitonin should not be seen as the marker of sepsis but as one of many potentially useful markers. (en)
Title	Procalcitonin - a marker and mediator of inflammation Procalcitonin - a marker and mediator of inflammation (en)
skos:prefLabel	Procalcitonin - a marker and mediator of inflammation Procalcitonin - a marker and mediator of inflammation (en)
skos:notation	RIV/00843989:_____/05:00012365!RIV10-MZ0-00843989
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	NEISER, Jan Zaoral, Tomáš Hladíková, Andrea Hladík, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	538926
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/05:00012365
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	procalcitonin (en)
http://linked.open.../riv/klicoveSlovo	procalcitonin
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CD8FD4926385]
http://linked.open...i/riv/nazevZdroje	Acta chirurgiae plasticae
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Neiser, Jan Zaoral, Tomáš Hladík, Michal Olosová, Andrea
issn	0001-5423
number of pages	4 (xsd:int)

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