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| rdfs:seeAlso
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| Description
| - AIM To examine skin perfusion in dependency on insulinemia in healthy subjects. METHODS: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by ethical committee. In our study a two-stage hyperinsulinemic euglycaemic clamp was performed, with insulinemia 100 and 250 mIU/mL and glycaemia 5.0 mmol/L (3% standard deviation). Before the clamp and in steady states, microcirculation was measured by laser-doppler flowmetry and transcutaneous oximetry and energy expenditure was measured by indirect calorimetry. Results (average and standard deviation) were evaluated with paired t-test. RESULTS: Physiological (50 mIU/L) insulinemia leaded to higher perfusion in both tests- hyperemia after heating to 44 oC- 1848% (984 - 2046) vs 1599% (801 - 1836), P < 0.05, half time of reaching peak perfusion after occlusion release 1.2 s (0.9 - 2.6) vs 4.9 s (1.8 - 11.4), P < 0.05. Supraphysiological (150 mIU/L) insulinemia leaded to even higher perfusion in both tests - hyperemia after heating to 44 oC - 1937% (1177 - 2488) vs 1599% (801 - 1836), P < 0.005, half time to reach peak perfusion after occlusion release 1.0 s (0.7 - 1.1) vs 4.9 s (1.8 - 11.4), P < 0.005. There occurred a statistically significant increase in tissue oxygenation in both insulinemia. The difference in perfusion and oxygenation between physiological and supraphysiological hyperinsulinemia were not statistically significant. CONCLUSION: Post occlusive hyperemia test in accordance with heating test showed significantly increasing skin perfusion in the course of artificial hyperinsulinemia. This effect rises non-linearly with increasing insulinemia. Dependency on the dose was not statistically significant.
- AIM To examine skin perfusion in dependency on insulinemia in healthy subjects. METHODS: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by ethical committee. In our study a two-stage hyperinsulinemic euglycaemic clamp was performed, with insulinemia 100 and 250 mIU/mL and glycaemia 5.0 mmol/L (3% standard deviation). Before the clamp and in steady states, microcirculation was measured by laser-doppler flowmetry and transcutaneous oximetry and energy expenditure was measured by indirect calorimetry. Results (average and standard deviation) were evaluated with paired t-test. RESULTS: Physiological (50 mIU/L) insulinemia leaded to higher perfusion in both tests- hyperemia after heating to 44 oC- 1848% (984 - 2046) vs 1599% (801 - 1836), P < 0.05, half time of reaching peak perfusion after occlusion release 1.2 s (0.9 - 2.6) vs 4.9 s (1.8 - 11.4), P < 0.05. Supraphysiological (150 mIU/L) insulinemia leaded to even higher perfusion in both tests - hyperemia after heating to 44 oC - 1937% (1177 - 2488) vs 1599% (801 - 1836), P < 0.005, half time to reach peak perfusion after occlusion release 1.0 s (0.7 - 1.1) vs 4.9 s (1.8 - 11.4), P < 0.005. There occurred a statistically significant increase in tissue oxygenation in both insulinemia. The difference in perfusion and oxygenation between physiological and supraphysiological hyperinsulinemia were not statistically significant. CONCLUSION: Post occlusive hyperemia test in accordance with heating test showed significantly increasing skin perfusion in the course of artificial hyperinsulinemia. This effect rises non-linearly with increasing insulinemia. Dependency on the dose was not statistically significant. (en)
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| Title
| - Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers
- Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers (en)
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| skos:prefLabel
| - Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers
- Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers (en)
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| skos:notation
| - RIV/00669806:_____/13:10145795!RIV14-MZ0-00669806
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00669806:_____/13:10145795
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Microcirculation; Laser-doppler flowmetry; Insulin; Diabetes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - CN - Čínská lidová republika
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - World Journal of Diabetes
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Rušavý, Zdeněk
- Jankovec, Zdeněk
- Krčma, Michal
- Žourek, Michal
- Lacigová, Silvie
- Čechurová, Daniela
- Brožová, Jitka
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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