About: Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells

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About: Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The antineoplastic alkaloid ellipticine is a prodrug, of which the pharmacological efficiency is dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation to 12-hydroxy- and 13-hydroxyellipticine, which are both the metabolites forming DNA adducts in target tissues. Using the method of Western blotting, the expression of CYP1A1, 1B1, 3A4, lactoperoxidase, thyroid peroxidase, cyclooxygenase-1 and cytochrome b5, the enzymes that catalyze and/or influence ellipticine metabolism, was investigated in several cancer cells sensitive to ellipticine (HL-60 promyelocytic leukemia and T-cell leukemia CCRF-CEM cells, glioblastoma U87MG cells, thyroid cancer BHT-101, B-CPAP and 8505-C cells, neuroblastoma UKF-NB-3 and UKF-NB-4 cell lines and breast adenocarcinoma MCF-7 cells). The findings summarized from several former studies reviewed in this study, together with new results indicate that, depending on individual cells, cytotoxicity of ellipticine, which is mediated by formation of covalent D The antineoplastic alkaloid ellipticine is a prodrug, of which the pharmacological efficiency is dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation to 12-hydroxy- and 13-hydroxyellipticine, which are both the metabolites forming DNA adducts in target tissues. Using the method of Western blotting, the expression of CYP1A1, 1B1, 3A4, lactoperoxidase, thyroid peroxidase, cyclooxygenase-1 and cytochrome b5, the enzymes that catalyze and/or influence ellipticine metabolism, was investigated in several cancer cells sensitive to ellipticine (HL-60 promyelocytic leukemia and T-cell leukemia CCRF-CEM cells, glioblastoma U87MG cells, thyroid cancer BHT-101, B-CPAP and 8505-C cells, neuroblastoma UKF-NB-3 and UKF-NB-4 cell lines and breast adenocarcinoma MCF-7 cells). The findings summarized from several former studies reviewed in this study, together with new results indicate that, depending on individual cells, cytotoxicity of ellipticine, which is mediated by formation of covalent D (en)
Title	Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study (en)
skos:prefLabel	Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study (en)
skos:notation	RIV/00216305:26620/14:PU112646!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP301/10/0356), S
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Adam, Vojtěch Kizek, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	16155
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU112646
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ellipticine, Cancer Cells, Cytotoxicity, Cytochromes P450, Peroxidases, Protein Expression, Western Blotting, Metabolizmus, DNA adukty (en)
http://linked.open.../riv/klicoveSlovo	Cytochromes P450 Protein Expression Western Blotting Cytotoxicity Ellipticine Cancer Cells DNA adukty Metabolizmus Peroxidases
http://linked.open...odStatuVydavatele	RS - Srbská republika
http://linked.open...ontrolniKodProRIV	[AC843674D556]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Frei, Eva Kizek, René Poljaková, Jitka Stiborová, Marie Bořek-Dohalská, Lucie Mřížová, Iveta
issn	1452-3981
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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