About: Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one

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About: Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis. A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis. (en)
Title	Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one (en)
skos:prefLabel	Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one (en)
skos:notation	RIV/00216305:26620/14:PU112541!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.30.0005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Abdel-Lattif, Abdel-Mohsan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	49052
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU112541
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-glycosyl, phthalazinone, antimicrobial activity, Benzamidazole (en)
http://linked.open.../riv/klicoveSlovo	antimicrobial activity Benzamidazole N-glycosyl phthalazinone
http://linked.open...odStatuVydavatele	CN - Čínská lidová republika
http://linked.open...ontrolniKodProRIV	[A81939C982F1]
http://linked.open...i/riv/nazevZdroje	Life Science Journal
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Support of Interdisciplinary Excellence Research Teams Establishment at BUT
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Abdel-Lattif, Abdel-Mohsan El-Shamy, Ibrahim E. Al-Shamrani, Khalid M. Al-Shehri, Mohammed M. Bakeer, Hadeer M.
issn	1097-8135
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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