About: Electrochemical and spectroemtric study of GFP-AZT interaction

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the last 18 years the highly active antiretroviral therapy (HAART) has been used for the treatment of HIV and consists of the combination of various drugs. The introduction of this type of treatment caused a significant extension of lives of patients and a reduction of side effects. However, the complete recovery of patients with HIV is still impossible. Azidothymidine (AZT) was the first drug used for the treatment of HIV and it is used in a combination with other drugs in HAART. Although the mechanism of effect of this drug is known, the mechanisms of side effects are still not sufficiently clarified. The way how to orient even in these reactions is the use of markers that allow in vivo monitoring of biological processes associated with the drug. As a fluorescent label the green fluorescent protein (GFP) can be used. In this study, we evaluated the link between AZT and GFP by electrochemical methods and also the change of the properties of GFP fluorescence after the binding/intercalating of AZT. In the last 18 years the highly active antiretroviral therapy (HAART) has been used for the treatment of HIV and consists of the combination of various drugs. The introduction of this type of treatment caused a significant extension of lives of patients and a reduction of side effects. However, the complete recovery of patients with HIV is still impossible. Azidothymidine (AZT) was the first drug used for the treatment of HIV and it is used in a combination with other drugs in HAART. Although the mechanism of effect of this drug is known, the mechanisms of side effects are still not sufficiently clarified. The way how to orient even in these reactions is the use of markers that allow in vivo monitoring of biological processes associated with the drug. As a fluorescent label the green fluorescent protein (GFP) can be used. In this study, we evaluated the link between AZT and GFP by electrochemical methods and also the change of the properties of GFP fluorescence after the binding/intercalating of AZT. (en)
Title	Electrochemical and spectroemtric study of GFP-AZT interaction Electrochemical and spectroemtric study of GFP-AZT interaction (en)
skos:prefLabel	Electrochemical and spectroemtric study of GFP-AZT interaction Electrochemical and spectroemtric study of GFP-AZT interaction (en)
skos:notation	RIV/00216305:26620/14:PU110412!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.4.31.0023)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kenšová, Renata Trnková, Libuše Kynický, Jindřich Adam, Vojtěch Kizek, René Zítka, Ondřej Komínková, Markéta Guráň, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	14091
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU110412
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Azidothymidine (AZT), zidovudine, green fluorescent protein (GFP), HIV (en)
http://linked.open.../riv/klicoveSlovo	Azidothymidine (AZT) green fluorescent protein (GFP) zidovudine HIV
http://linked.open...odStatuVydavatele	RS - Srbská republika
http://linked.open...ontrolniKodProRIV	[F6AA66D04A41]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Partner Network for Bionanotechnological and Metallomic Research
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Kizek, René Kynický, Jindřich Trnková, Libuše Zítka, Ondřej Komínková, Markéta Kenšová, Renáta Guráň, Roman
issn	1452-3981
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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