About: Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times. This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times. (en)
Title	Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods (en)
skos:prefLabel	Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods (en)
skos:notation	RIV/00216305:26620/14:PU108617!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	O P
http://linked.open...avai/riv/aktivity	O, P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Adam, Vojtěch Kizek, René Zítka, Ondřej Ruttkay-Nedecký, Branislav Komínková, Markéta Kopel, Pavel Guráň, Roman Merlos Rodrigo, Miguel Ángel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	48268
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU108617
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Liposome, Cholesterol, Doxorubicin, Sodium Dodecyl Sulphate, Drug Delivery, Drug Encapsulation, (en)
http://linked.open.../riv/klicoveSlovo	Doxorubicin Drug Delivery Drug Encapsulation Sodium Dodecyl Sulphate Cholesterol Liposome
http://linked.open...odStatuVydavatele	RS - Srbská republika
http://linked.open...ontrolniKodProRIV	[796566A1F442]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Kizek, René Zítka, Ondřej Ruttkay-Nedecký, Branislav Blažková, Iva Kopel, Pavel Komínková, Markéta Nejdl, Lukáš Heger, Zbyněk Merlos Rodrigo, Miguel Ángel Chudobová, Dagmar Guráň, Roman
issn	1452-3981
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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