About: Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A diagnostics of infectious diseases can be done by the immunologic methods or by the amplification of nucleic acid specific to contagious agent using polymerase chain reaction. However, in transmissible spongiform encephalopathies, the infectious agent, prion protein (PrPSc), has the same sequence of nucleic acids as a naturally occurring protein. The other issue with the diagnosing based on the PrPSc detection is that the pathological form of prion protein is abundant only at late stages of the disease in a brain. Therefore, the diagnostics of prion protein caused diseases represent a sort of challenges as that hosts can incubate infectious prion proteins for many months or even years. Therefore, new in vivo assays for detection of prion proteins and for diagnosis of their relation to neurodegenerative diseases are summarized. Their applicability and future prospects in this field are discussed with particular aim at using quantum dots as fluorescent labels. A diagnostics of infectious diseases can be done by the immunologic methods or by the amplification of nucleic acid specific to contagious agent using polymerase chain reaction. However, in transmissible spongiform encephalopathies, the infectious agent, prion protein (PrPSc), has the same sequence of nucleic acids as a naturally occurring protein. The other issue with the diagnosing based on the PrPSc detection is that the pathological form of prion protein is abundant only at late stages of the disease in a brain. Therefore, the diagnostics of prion protein caused diseases represent a sort of challenges as that hosts can incubate infectious prion proteins for many months or even years. Therefore, new in vivo assays for detection of prion proteins and for diagnosis of their relation to neurodegenerative diseases are summarized. Their applicability and future prospects in this field are discussed with particular aim at using quantum dots as fluorescent labels. (en)
Title	Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging? Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging? (en)
skos:prefLabel	Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging? Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging? (en)
skos:notation	RIV/00216305:26620/13:PU106832!RIV14-GA0-26620___
http://linked.open...avai/riv/aktivita	O P
http://linked.open...avai/riv/aktivity	O, P(ED1.1.00/02.0068), P(GP13-20303P)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ryvolová, Markéta Chomoucká, Jana Adam, Vojtěch Drbohlavová, Jana Hubálek, Jaromír Kizek, René Kopel, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	101226
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/13:PU106832
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	imaging, label, neurodegenerative disease, prion protein, quantum dots (en)
http://linked.open.../riv/klicoveSlovo	imaging neurodegenerative disease label prion protein quantum dots
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DC8C49CDB627]
http://linked.open...i/riv/nazevZdroje	PRION
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Labelling of proteins with quantum dots and their sensing using microfluidic system Central european institute of technology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Chomoucká, Jana Drbohlavová, Jana Hubálek, Jaromír Kizek, René Vaculovičová, Markéta Šobrová, Pavlína Blažková, Iva Kopel, Pavel
http://linked.open...ain/vavai/riv/wos	000327383600001
issn	1933-6896
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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