About: Thermogelling properties of injectable functionalized hydrogels

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Proposed work deals with preparation, characterization and rheological study of well-defined smart injectable hydrogels from biodegradable, biocompatible, controlled life-time copolymers based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly([(lactic acid)-co-(glycolic acid)] (PLA/PGA) copolymer. Thermosensitive PLGA-PEG-PLGA copolymer with PLGA/PEG weight ratio of 1.5; 2; 2.5; 3.0 and LA/GA molar ratio equal to 2.4; 3.0 and 3.4 were prepared and additionally functionalized by itaconic anhydride (ITA) bringing both reactive carbon double bonds and functional -COOH groups to polymer both ends. Aqueous solutions of both modified and unmodified copolymers are able to form free flowing sol at room temperature and clear gel at temperature around 37 deg.C. Therefore, sol-gel transitions, thermogelling and viscoelastic properties were investigated using both test tube inverting method (TTIM) and rheometer. Combined methods give comprehensive information about changing in color, viscosity, elas Proposed work deals with preparation, characterization and rheological study of well-defined smart injectable hydrogels from biodegradable, biocompatible, controlled life-time copolymers based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly([(lactic acid)-co-(glycolic acid)] (PLA/PGA) copolymer. Thermosensitive PLGA-PEG-PLGA copolymer with PLGA/PEG weight ratio of 1.5; 2; 2.5; 3.0 and LA/GA molar ratio equal to 2.4; 3.0 and 3.4 were prepared and additionally functionalized by itaconic anhydride (ITA) bringing both reactive carbon double bonds and functional -COOH groups to polymer both ends. Aqueous solutions of both modified and unmodified copolymers are able to form free flowing sol at room temperature and clear gel at temperature around 37 deg.C. Therefore, sol-gel transitions, thermogelling and viscoelastic properties were investigated using both test tube inverting method (TTIM) and rheometer. Combined methods give comprehensive information about changing in color, viscosity, elas (en)
Title	Thermogelling properties of injectable functionalized hydrogels Thermogelling properties of injectable functionalized hydrogels (en)
skos:prefLabel	Thermogelling properties of injectable functionalized hydrogels Thermogelling properties of injectable functionalized hydrogels (en)
skos:notation	RIV/00216305:26620/12:PU102272!RIV13-MSM-26620___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vojtová, Lucy Jančář, Josef Chamradová, Ivana Michlovská, Lenka
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	174321
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/12:PU102272
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	injectable hydrogels, sol-gel transition, rheology, viscoelastic properties (en)
http://linked.open.../riv/klicoveSlovo	injectable hydrogels rheology sol-gel transition viscoelastic properties
http://linked.open...ontrolniKodProRIV	[E5B0151CA3E5]
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Jančář, Josef Vojtová, Lucy Michlovská, Lenka Chamradová, Ivana
http://localhost/t...ganizacniJednotka	26620

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