About: The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin

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About: The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is known that cells and organisms can indirectly sense changes in l-arginine availability via changes in the activity of various metabolic pathways. However, the mechanism(s) by which genes can be directly regulated by l-arginine in mammalian cells have not yet been elucidated. We investigated the effect of l-arginine in the in vivo model of peritoneal inflammation in mice and in vitro in RAW 264.7 macrophages. A detailed analysis of basic physiological functions and selected intracellular signaling cascades revealed that l-arginine is crucial for the acceleration of macrophage activation by bacterial lipopolysaccharide. l-arginine increased the production of reactive oxygen species, nitric oxide, release of Ca2+, as well as inducible nitric oxide synthase expression. Interestingly, the effect of l-arginine on macrophage activation was dependent on the phosphorylation of mitogen-activated protein kinases and activity of phospholipase C. In RAW 264.7 cells, l-arginine was shown to modulate the respo It is known that cells and organisms can indirectly sense changes in l-arginine availability via changes in the activity of various metabolic pathways. However, the mechanism(s) by which genes can be directly regulated by l-arginine in mammalian cells have not yet been elucidated. We investigated the effect of l-arginine in the in vivo model of peritoneal inflammation in mice and in vitro in RAW 264.7 macrophages. A detailed analysis of basic physiological functions and selected intracellular signaling cascades revealed that l-arginine is crucial for the acceleration of macrophage activation by bacterial lipopolysaccharide. l-arginine increased the production of reactive oxygen species, nitric oxide, release of Ca2+, as well as inducible nitric oxide synthase expression. Interestingly, the effect of l-arginine on macrophage activation was dependent on the phosphorylation of mitogen-activated protein kinases and activity of phospholipase C. In RAW 264.7 cells, l-arginine was shown to modulate the respo (en)
Title	The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin (en)
skos:prefLabel	The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin (en)
skos:notation	RIV/00216305:26620/12:PU100939!RIV14-MSM-26620___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(ED1.100/02/0123), P(GA524/08/1753), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kadlec, Jaroslav Kuchta, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	112621
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/12:PU100939
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Macrophages, l-arginine, Lipopolysaccharide, Mitogen-activated protein kinases, Phospholipase C, G-protein-coupled receptor (en)
http://linked.open.../riv/klicoveSlovo	Lipopolysaccharide Macrophages G-protein-coupled receptor Mitogen-activated protein kinases l-arginine Phospholipase C
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1F7F2DF9F485]
http://linked.open...i/riv/nazevZdroje	IMMUNOLOGIC RESEARCH
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology The influence of L-arginine and its analogues on the generation of reactive oxygen and nitrogen species by professional phagocytes St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	2012
http://linked.open...iv/tvurceVysledku	Kuchta, Radek Kadlec, Jaroslav Pekarová, Michaela
http://linked.open...ain/vavai/riv/wos	000298416400011
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0257-277X
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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