About: Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants

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About: Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CTAB and Septonex are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of CTAB or Septonex with oppositely charged hyaluronic acid were prepared primarily by their electrostatic interactions with the aim of their potential application in drug delivery. Hyaluronic acid seems to be promising biomaterial of near future due to its broad range of biological functions - combination of its biocompatibility and biodegradability properties and its susceptibility of chemical modifications. Hyaluronic acid can serve as a biocompatible carrier of a delivery system in which the surfactant serves as a solubilizer for hydrophobic active substance (drug). Our data show, that hyaluronic acid complexes with CTAB or Septonex reduce cytotoxicity of both antiseptics in all concentrations tested. CTAB and Septonex are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of CTAB or Septonex with oppositely charged hyaluronic acid were prepared primarily by their electrostatic interactions with the aim of their potential application in drug delivery. Hyaluronic acid seems to be promising biomaterial of near future due to its broad range of biological functions - combination of its biocompatibility and biodegradability properties and its susceptibility of chemical modifications. Hyaluronic acid can serve as a biocompatible carrier of a delivery system in which the surfactant serves as a solubilizer for hydrophobic active substance (drug). Our data show, that hyaluronic acid complexes with CTAB or Septonex reduce cytotoxicity of both antiseptics in all concentrations tested. (en)
Title	Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants (en)
skos:prefLabel	Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants (en)
skos:notation	RIV/00216305:26310/14:PU110567!RIV15-MSM-26310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LD12068)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Mravec, Filip Halasová, Tereza Pekař, Miloslav
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta chemická
http://linked.open...dnocenehoVysledku	20030
http://linked.open...ai/riv/idVysledku	RIV/00216305:26310/14:PU110567
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hyaluronan, surfactants, CTAB, Septonex, cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity CTAB Septonex surfactants hyaluronan
http://linked.open...ontrolniKodProRIV	[5366A78398B3]
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Preparation of hyaluronan-micellar-aggregate colloids for nanomedical applications and characterization of their properties
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Mravec, Filip Pekař, Miloslav Kalbáčová, Marie Verdánová, Martina Venerová, Tereza
http://localhost/t...ganizacniJednotka	26310

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