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  • The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular struc
  • The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular struc (en)
Title
  • The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application
  • The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application (en)
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  • The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application
  • The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application (en)
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  • RIV/00216305:26310/13:PU105842!RIV14-MSM-26310___
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  • RIV/00216305:26310/13:PU105842
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  • nanoparticles, surface modification, stability, particle size, particle shape, structure (en)
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  • Jiřík, Radovan
  • Kalina, Michal
  • Skládal, Petr
  • Starčuk, Zenon
  • Kovář, David
  • Fohlerová, Zdenka
  • Malá, Aneta
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  • 26310
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