About: Chiral Analysis of Drug Residuals in Wastewaters

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Many of the pharmacologically active substances present in the environment are chiral. However, there is only little data concerning their fate in the environment on the enantiomeric level. Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in biological system such as human body. Therefore, stereoselective behaviour of chiral drugs is very likely to happen in the environment. Enantioselective HPLC-DAD method using Chiralpak AD as a chiral column was developed for the analysis of two non-steroidal anti-inflammatory drugs ibuprofen and ketoprofen in wastewater samples. Before the chiral analysis was applied, the sum of enantiomers was quantified by HPLC-ESI-MS. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive and selective enough for the chiral analysis of wastewater samples. Drugs are generally present in the wastewater in very small amounts and when they are divided into in Many of the pharmacologically active substances present in the environment are chiral. However, there is only little data concerning their fate in the environment on the enantiomeric level. Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in biological system such as human body. Therefore, stereoselective behaviour of chiral drugs is very likely to happen in the environment. Enantioselective HPLC-DAD method using Chiralpak AD as a chiral column was developed for the analysis of two non-steroidal anti-inflammatory drugs ibuprofen and ketoprofen in wastewater samples. Before the chiral analysis was applied, the sum of enantiomers was quantified by HPLC-ESI-MS. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive and selective enough for the chiral analysis of wastewater samples. Drugs are generally present in the wastewater in very small amounts and when they are divided into in (en)
Title	Chiral Analysis of Drug Residuals in Wastewaters Chiral Analysis of Drug Residuals in Wastewaters (en)
skos:prefLabel	Chiral Analysis of Drug Residuals in Wastewaters Chiral Analysis of Drug Residuals in Wastewaters (en)
skos:notation	RIV/00216305:26310/11:PU93670!RIV12-MSM-26310___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Čáslavský, Josef Svobodová, Dagmar
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta chemická
http://linked.open...dnocenehoVysledku	190195
http://linked.open...ai/riv/idVysledku	RIV/00216305:26310/11:PU93670
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chiral pharmaceuticals, chiral analysis, non-steroidal anti-inflammatory drugs, ibuprofen, ketoprofen (en)
http://linked.open.../riv/klicoveSlovo	ibuprofen ketoprofen chiral analysis chiral pharmaceuticals non-steroidal anti-inflammatory drugs
http://linked.open...ontrolniKodProRIV	[5B1A590194AA]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Svobodová, Dagmar Čáslavský, Josef
http://localhost/t...ganizacniJednotka	26310

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