About: Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Eukaryotic genomes are rich in sequences capable of forming non-B DNA structures. These structures are expected to play important roles in natural regulatory processes at levels above those of individual genes, such as whole genome dynamics or chromatin organization, as well as in processes leading to the loss of these functions, such as cancer development. Recently, a number of authors have mapped the occurrence of potential quadruplex sequences in the human genome and found them to be associated with promoters. In this paper, we set out to map the distribution and characteristics of potential triplex-forming sequences in human genome DNA sequences. Using the R/Bioconductor package triplex, we found these sequences to be excluded from exons, while present mostly in a small number of repetitive sequence classes, especially short sequence tandem repeats (microsatellites), Alu and combined elements, such as SVA. We also introduce a novel way of classifying potential triplex sequences, using Eukaryotic genomes are rich in sequences capable of forming non-B DNA structures. These structures are expected to play important roles in natural regulatory processes at levels above those of individual genes, such as whole genome dynamics or chromatin organization, as well as in processes leading to the loss of these functions, such as cancer development. Recently, a number of authors have mapped the occurrence of potential quadruplex sequences in the human genome and found them to be associated with promoters. In this paper, we set out to map the distribution and characteristics of potential triplex-forming sequences in human genome DNA sequences. Using the R/Bioconductor package triplex, we found these sequences to be excluded from exons, while present mostly in a small number of repetitive sequence classes, especially short sequence tandem repeats (microsatellites), Alu and combined elements, such as SVA. We also introduce a novel way of classifying potential triplex sequences, using (en)
Title	Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex (en)
skos:prefLabel	Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex (en)
skos:notation	RIV/00216305:26230/14:PU111943!RIV15-MSM-26230___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0070), P(EE2.3.20.0189), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Martínek, Tomáš
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta informačních technologií
http://linked.open...dnocenehoVysledku	51932
http://linked.open...ai/riv/idVysledku	RIV/00216305:26230/14:PU111943
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Human genome, DNA sequence, Non-B-DNA, Triplex, Bioconductor, Repetitive sequences, Mobile DNA, Lexicographically minimal rotation (en)
http://linked.open.../riv/klicoveSlovo	Repetitive sequences Bioconductor Triplex DNA sequence Human genome Lexicographically minimal rotation Mobile DNA Non-B-DNA
http://linked.open...ontrolniKodProRIV	[79E629968F65]
http://linked.open...v/mistoKonaniAkce	Angers
http://linked.open...i/riv/mistoVydani	Angers
http://linked.open...i/riv/nazevZdroje	Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
http://linked.open...in/vavai/riv/obor	IN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of excellence in evolutionary cytogenomics, epigenetics and cell signalling IT4Innovations Centre of Excellence
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Brázdová, Marie Lexa, Matej Martínek, Tomáš
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2014-03-03 (xsd:date)
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.5220/0004824100800088
http://purl.org/ne...btex#hasPublisher	SciTePress - Science and Technology Publications
https://schema.org/isbn	978-989-758-012-3
http://localhost/t...ganizacniJednotka	26230

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