About: Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 23+/-1 C. Ethanol reversibly affected I(K1) in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanol significantly decreased IK1 by 6.9+/-2.7%. However, at concentrations of ethanol >=20 mM (0.09%), I(K1) was conversely significantly increased (by 16.6+/-4.0% at 20 mM and 24.5+/-2.4% at 80 mM). The steady-state I(K1) increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, I(K1) was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effects Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 23+/-1 C. Ethanol reversibly affected I(K1) in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanol significantly decreased IK1 by 6.9+/-2.7%. However, at concentrations of ethanol >=20 mM (0.09%), I(K1) was conversely significantly increased (by 16.6+/-4.0% at 20 mM and 24.5+/-2.4% at 80 mM). The steady-state I(K1) increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, I(K1) was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effects (en)
Title	Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes (en)
skos:prefLabel	Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes (en)
skos:notation	RIV/00216305:26220/14:PU111652!RIV15-MSM-26220___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pásek, Michal Šimurda, Jiří Matejovič, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	12464
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/14:PU111652
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Arrhythmia, Dual effect, Ethanol, Inward rectifier, Rat ventricular action potential model, Rat ventricular myocytes (en)
http://linked.open.../riv/klicoveSlovo	Dual effect Inward rectifier Rat ventricular action potential model Rat ventricular myocytes Ethanol Arrhythmia
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[F9BB3EE0AEFF]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Bébarová, Markéta Pásek, Michal Šimurda, Jiří Šimurdová, Milena Matejovič, Peter
issn	0867-5910
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	26220

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