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rdf:type
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Description
| - Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 23+/-1 C. Ethanol reversibly affected I(K1) in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanol significantly decreased IK1 by 6.9+/-2.7%. However, at concentrations of ethanol >=20 mM (0.09%), I(K1) was conversely significantly increased (by 16.6+/-4.0% at 20 mM and 24.5+/-2.4% at 80 mM). The steady-state I(K1) increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, I(K1) was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effects
- Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 23+/-1 C. Ethanol reversibly affected I(K1) in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanol significantly decreased IK1 by 6.9+/-2.7%. However, at concentrations of ethanol >=20 mM (0.09%), I(K1) was conversely significantly increased (by 16.6+/-4.0% at 20 mM and 24.5+/-2.4% at 80 mM). The steady-state I(K1) increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, I(K1) was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effects (en)
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Title
| - Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes
- Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes (en)
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skos:prefLabel
| - Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes
- Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes (en)
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skos:notation
| - RIV/00216305:26220/14:PU111652!RIV15-MSM-26220___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216305:26220/14:PU111652
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Arrhythmia, Dual effect, Ethanol, Inward rectifier, Rat ventricular action potential model, Rat ventricular myocytes (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bébarová, Markéta
- Pásek, Michal
- Šimurda, Jiří
- Šimurdová, Milena
- Matejovič, Peter
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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