About: Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

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About: Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol. Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol. (en) Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol. (cs)
Title	Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram (en) Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram (cs)
skos:prefLabel	Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram (en) Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram (cs)
skos:notation	RIV/00216305:26220/06:PU62586!RIV06-GA0-26220___
http://linked.open.../vavai/riv/strany	1-4
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA102/04/0472), P(GA305/04/1385), Z(MSM0021630513)
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Kolářová, Jana Nováková, Marie Provazník, Ivo
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	473196
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/06:PU62586
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sigma receptor, haloperidol, isolated heart, electrogram (en)
http://linked.open.../riv/klicoveSlovo	sigma receptor electrogram haloperidol isolated heart
http://linked.open...ontrolniKodProRIV	[72F7924AA376]
http://linked.open...v/mistoKonaniAkce	Valencia
http://linked.open...i/riv/mistoVydani	Valencia
http://linked.open...i/riv/nazevZdroje	Computers in Cardiology 2006
http://linked.open...in/vavai/riv/obor	JD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart High resolution optical recording of action potentials for analysis of T-wave alternans
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Provazník, Ivo Nováková, Marie Bardoňová, Jana
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2006-09-17 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Advanced Electronic Communication Systems and Technologies (ELCOM)
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	IEEE
https://schema.org/isbn	0-7803-8894-1
http://localhost/t...ganizacniJednotka	26220

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