About: Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Halooperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-time changes in s Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Halooperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-time changes in s (en)
Title	Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart (en)
skos:prefLabel	Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart (en)
skos:notation	RIV/00216305:26220/01:PU20112!RIV/2002/GA0/262202/N
http://linked.open.../vavai/riv/strany	418-421
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA102/01/1494)
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Kolářová, Jana Provazník, Ivo
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	702172
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/01:PU20112
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sigma ligand, heart, wavelet analysis (en)
http://linked.open.../riv/klicoveSlovo	heart wavelet analysis sigma ligand
http://linked.open...ontrolniKodProRIV	[9299D16CEBF0]
http://linked.open...v/mistoKonaniAkce	Pula, Croatia
http://linked.open...i/riv/mistoVydani	Pula, Chorvatsko
http://linked.open...i/riv/nazevZdroje	Medicon 2001, iX Mediterranean Conference on Medical and BIological Engineering and Computing
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Optical recording of action potentials and its application in cardiology
http://linked.open...UplatneniVysledku	2001
http://linked.open...iv/tvurceVysledku	Provazník, Ivo Nováková, Marie Bardoňová, Jana
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2001-06-12 (xsd:date)
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	International Federation for MEdical and Biological Engineering
http://localhost/t...ganizacniJednotka	26220

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software