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  • The threedimensional finite element (FE) model of eucaryotic cell presented in the paper comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing cytoskeleton. In contrast to the previous models, this tensegrity structure consists of several parts. External and internal parts count 30 struts and 60 cables each and their corresponding nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate the load transmission from the extracellular space via membrane receptors (focal adhesions) to the central part of the cell (nucleus, centrosome); this ability of the model was tested by simulation of some mechanical tests of isolated cells, in particular tension test with micropipettes, indentation test and magnetic tweezer test. Although material properties of compo-nents have been defined as realistic as possible on the base of the mechanical t
  • The threedimensional finite element (FE) model of eucaryotic cell presented in the paper comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing cytoskeleton. In contrast to the previous models, this tensegrity structure consists of several parts. External and internal parts count 30 struts and 60 cables each and their corresponding nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate the load transmission from the extracellular space via membrane receptors (focal adhesions) to the central part of the cell (nucleus, centrosome); this ability of the model was tested by simulation of some mechanical tests of isolated cells, in particular tension test with micropipettes, indentation test and magnetic tweezer test. Although material properties of compo-nents have been defined as realistic as possible on the base of the mechanical t (en)
Title
  • Finite element simulation of mechanical tests of individual cells.
  • Finite element simulation of mechanical tests of individual cells. (en)
skos:prefLabel
  • Finite element simulation of mechanical tests of individual cells.
  • Finite element simulation of mechanical tests of individual cells. (en)
skos:notation
  • RIV/00216305:26210/09:PU83928!RIV13-GA0-26210___
http://linked.open...avai/riv/aktivita
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  • P(GA106/09/1732)
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  • 315090
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  • RIV/00216305:26210/09:PU83928
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  • Cell biomechanics, tensegrity structure, cytoskeleton, mechanical properties, finite element model (en)
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  • [1DF3F8448A07]
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  • Mnichov
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  • Munich, Germany
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  • IFMBE Proceedings
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  • Burša, Jiří
  • Fuis, Vladimír
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000282043000006
http://linked.open.../riv/zahajeniAkce
number of pages
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  • Springer-Verlag
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  • 978-3-642-03897-6
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  • 26210
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