About: Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Environmental contamination by energetic materials is an acute problem, and nitramine compds. are one of the major groups of such type contaminants. One of the initial stages of biodegradation and/or toxic action of such compounds is frequently related to their 1e-/2e-(4e-) reduction catalyzed by redox-active flavoenzymes. The enzymic reactivity of TNAZ and CL-20 (HNIW) - was examined towards single- and two-electron transferring flavoenzymes and their electron-accepting potency was assessed by electrochem. and quantum mechanical methods. The standard nitramine RDX was also used. The found reactivity increased with an increase in the electron-accepting potency of the compds. TNAZ and CL-20 were found to be much more toxic compds. for mice splenocytes than RDX. This toxicity is much higher than that TEX and BCHMX. This work demonstrates that the cytotoxicity of the compounds is caused mainly by their electron-accepting potency and might be influenced by their structural peculiarities. Environmental contamination by energetic materials is an acute problem, and nitramine compds. are one of the major groups of such type contaminants. One of the initial stages of biodegradation and/or toxic action of such compounds is frequently related to their 1e-/2e-(4e-) reduction catalyzed by redox-active flavoenzymes. The enzymic reactivity of TNAZ and CL-20 (HNIW) - was examined towards single- and two-electron transferring flavoenzymes and their electron-accepting potency was assessed by electrochem. and quantum mechanical methods. The standard nitramine RDX was also used. The found reactivity increased with an increase in the electron-accepting potency of the compds. TNAZ and CL-20 were found to be much more toxic compds. for mice splenocytes than RDX. This toxicity is much higher than that TEX and BCHMX. This work demonstrates that the cytotoxicity of the compounds is caused mainly by their electron-accepting potency and might be influenced by their structural peculiarities. (en)
Title	Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity (en)
skos:prefLabel	Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity Modern nitramines TNAZ and CL-20 (HNIW): their electron-accepting potency, enzymatic reactivity and cytotoxicity (en)
skos:notation	RIV/00216275:25310/14:39898736!RIV15-MSM-25310___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zeman, Svatopluk Elbeih, Ahmed Ikhlas Mohamed
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	30041
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/14:39898736
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	enzymatic reactions; flavoenzymes; cytotoxicity; toxicity; quantum mechanical calculation; peak potential; RDX; HNIW; CL-20; TNAZ; nitro group; caged nitramines; strained cyclic nitramines; high energy materials (en)
http://linked.open.../riv/klicoveSlovo	TNAZ caged nitramines high energy materials nitro group quantum mechanical calculation strained cyclic nitramines enzymatic reactions peak potential cytotoxicity CL-20 flavoenzymes toxicity HNIW RDX
http://linked.open...ontrolniKodProRIV	[BFFD9497DB24]
http://linked.open...v/mistoKonaniAkce	Pardubice
http://linked.open...i/riv/mistoVydani	Pardubice
http://linked.open...i/riv/nazevZdroje	New Trends in Research of Energetic Materials: proceedings of the 17th seminar
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Elbeih, Ahmed Ikhlas Mohamed Zeman, Svatopluk Anusevicius, Zilvinas Cenas, Narimantas Miliukiene, Vale Miseviciene, Lina Sarlauskas, Jonas Miseviciene, Kastis
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2014-04-09 (xsd:date)
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Pardubice
https://schema.org/isbn	978-80-7395-770-4
http://localhost/t...ganizacniJednotka	25310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software