About: Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase     Goto   Sponge   NotDistinct   Permalink

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  • Acetaminophen overdose is the most frequent cause of acute liver injury. The main mechanism of acetaminophen toxicity has been attributed to oxidation of acetaminophen. The type of enzyme inhibition was observed to be competitive in the cases of both APAP-SG and glutathione. As glutathione inhibits GR activity in cells under physiological conditions, the rate of enzyme inhibition ought to be weaker in the case of glutathione depletion that is typical of acetaminophen overdose. Notably, however, enzyme activity likely remains inhibited due to the presence of APAP-SG, which might enhance the pro-oxidative status in the cell.
  • Acetaminophen overdose is the most frequent cause of acute liver injury. The main mechanism of acetaminophen toxicity has been attributed to oxidation of acetaminophen. The type of enzyme inhibition was observed to be competitive in the cases of both APAP-SG and glutathione. As glutathione inhibits GR activity in cells under physiological conditions, the rate of enzyme inhibition ought to be weaker in the case of glutathione depletion that is typical of acetaminophen overdose. Notably, however, enzyme activity likely remains inhibited due to the presence of APAP-SG, which might enhance the pro-oxidative status in the cell. (en)
Title
  • Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase
  • Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase (en)
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  • Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase
  • Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase (en)
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  • RIV/00216275:25310/14:39898305!RIV15-MSM-25310___
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  • 8104
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  • RIV/00216275:25310/14:39898305
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  • glutathione reductase; glutathione; acetaminophen toxicity (en)
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  • US - Spojené státy americké
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  • [2F2B1B8391FE]
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  • Journal of Applied Toxicology
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  • 34
http://linked.open...iv/tvurceVysledku
  • Roušar, Tomáš
  • Ventura, Karel
  • Česla, Petr
  • Vrbová, Martina
  • Jankovičová, Barbora
  • Roušarová, Erika
http://linked.open...ain/vavai/riv/wos
  • 000340291200003
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  • 0260-437X
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  • 10.1002/jat.2914
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  • 25310
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