About: Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry

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About: Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	High-performance liquid chromatography (HPLC) coupled with electrospray ionization mass spectrometry (ESI-MS) was applied for the analysis of nabumetone metabolites during the biotransformation in minipigs. In addition to known phase I metabolites, the identification of phase II metabolites was achieved on the basis of their full-scan mass spectra and subsequent MSn analysis using both positive-ion and negative-ion ESI mode. Some phase I metabolites are conjugated with both glucuronide acid and glycine, which is quite unusual type of phase II metabolite not presented so far for nabumetone. These metabolites were found in small intestine content, but they were absent in minipigs urine. High-performance liquid chromatography (HPLC) coupled with electrospray ionization mass spectrometry (ESI-MS) was applied for the analysis of nabumetone metabolites during the biotransformation in minipigs. In addition to known phase I metabolites, the identification of phase II metabolites was achieved on the basis of their full-scan mass spectra and subsequent MSn analysis using both positive-ion and negative-ion ESI mode. Some phase I metabolites are conjugated with both glucuronide acid and glycine, which is quite unusual type of phase II metabolite not presented so far for nabumetone. These metabolites were found in small intestine content, but they were absent in minipigs urine. (en)
Title	Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry (en)
skos:prefLabel	Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry (en)
skos:notation	RIV/00216275:25310/14:39898170!RIV15-MSM-25310___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	January
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Holčapek, Michal Česlová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	20275
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/14:39898170
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tandem mass spectrometry; HPLC/MS; conjugation with glycine; conjugation with glucuronide acid; drug metabolites (en)
http://linked.open.../riv/klicoveSlovo	HPLC/MS tandem mass spectrometry conjugation with glucuronide acid conjugation with glycine drug metabolites
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[06AC34F922B0]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmaceutical and Biomedical Analysis
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Holčapek, Michal Nobilis, Milan Česlová, Lenka
http://linked.open...ain/vavai/riv/wos	000329532800031
issn	0731-7085
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jpba.2013.08.053
http://localhost/t...ganizacniJednotka	25310

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