About: Cyclic nitroamines: investigation of their electrochemical properties, cytotoxicity and enzymatic reactions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cyclic nitramines are one of the major group of contaminants of the environment. The toxic action and biodegrdn. of the above compds. are mostly related to their 1e-/2e-(4e-) redn. by flavoenzymes. In this work lab. scale quantities of 10 nitramines were estimated. Voltammetric redn. peak potentials (Ep,7) varied from -1580 mV to -555 mV vs. Ag/AgCl for NNHT and N,N'-dinitroimidazol-2-one, resp. Their cytotoxicity for mice splenocytes was investigated. N,N'-dinitroimidazol-2-one, N,N'-dinitropiperazine, K-6 (keto-RDX) and RDX were found to be the most toxic nitramines (CL50 - 45, 47, 67 and 140 microM) whereas compd. BCHMX was less toxic (CL50 = 160 microM). Preliminary evaluation of BCHMX for the acute oral toxicity on mice revealed, that it did not demonstrate any signs of an acute toxicity in oral doses less than 1000 mg/kg. Generally, bicyclic and cage nitramine HEMs were found to be less cytotoxic (CL50 = 160-350 microM) than mono-cyclic compds. Cyclic nitramines are one of the major group of contaminants of the environment. The toxic action and biodegrdn. of the above compds. are mostly related to their 1e-/2e-(4e-) redn. by flavoenzymes. In this work lab. scale quantities of 10 nitramines were estimated. Voltammetric redn. peak potentials (Ep,7) varied from -1580 mV to -555 mV vs. Ag/AgCl for NNHT and N,N'-dinitroimidazol-2-one, resp. Their cytotoxicity for mice splenocytes was investigated. N,N'-dinitroimidazol-2-one, N,N'-dinitropiperazine, K-6 (keto-RDX) and RDX were found to be the most toxic nitramines (CL50 - 45, 47, 67 and 140 microM) whereas compd. BCHMX was less toxic (CL50 = 160 microM). Preliminary evaluation of BCHMX for the acute oral toxicity on mice revealed, that it did not demonstrate any signs of an acute toxicity in oral doses less than 1000 mg/kg. Generally, bicyclic and cage nitramine HEMs were found to be less cytotoxic (CL50 = 160-350 microM) than mono-cyclic compds. (en)
Title	Cyclic nitroamines: investigation of their electrochemical properties, cytotoxicity and enzymatic reactions Cyclic nitroamines: investigation of their electrochemical properties, cytotoxicity and enzymatic reactions (en)
skos:prefLabel	Cyclic nitroamines: investigation of their electrochemical properties, cytotoxicity and enzymatic reactions Cyclic nitroamines: investigation of their electrochemical properties, cytotoxicity and enzymatic reactions (en)
skos:notation	RIV/00216275:25310/13:39897486!RIV14-MSM-25310___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Zeman, Svatopluk Elbeih, Ahmed Ikhlas Mohamed
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	67612
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/13:39897486
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	enzymatic reactions; enzyme PETN-reductase; cytotoxicity; peak potential; electrochemistry; synthesis; cyclic, bicyclic and cage N-nitroamines (en)
http://linked.open.../riv/klicoveSlovo	bicyclic and cage N-nitroamines enzymatic reactions enzyme PETN-reductase peak potential cytotoxicity cyclic electrochemistry synthesis
http://linked.open...ontrolniKodProRIV	[6FE3A03E8513]
http://linked.open...v/mistoKonaniAkce	Pardubice
http://linked.open...i/riv/mistoVydani	Pardubice
http://linked.open...i/riv/nazevZdroje	Proceedings of the 16th Seminar New Trends in Research of Energetic Materials
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Elbeih, Ahmed Ikhlas Mohamed Zeman, Svatopluk Anusevicius, Zilvinas Cenas, Narimantas Kristopaitis, Kastis Miliukiene, Vale Miseviciene, Lina Nivinskas, Henrikas Sarlauskas, Jonas Talaikis, Martynas
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2013-04-10 (xsd:date)
number of pages	9 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Pardubice
https://schema.org/isbn	978-80-7395-605-9
http://localhost/t...ganizacniJednotka	25310

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