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  • A liquid chromatography-tandem mass spectrometry method for the determination of two acetaminophen metabolites, i.e. acetaminophen-glutathione and acetaminophen-cysteine conjugates was developed. The octadecyl silica gel column has been used together with the gradient elution of methanol/water for fast separation of metabolites in less than four minutes. Tandem mass spectrometry in multiple reaction monitoring mode was applied for identification and quantitation of metabolites using deuterated acetaminophen as the internal standard.
  • A liquid chromatography-tandem mass spectrometry method for the determination of two acetaminophen metabolites, i.e. acetaminophen-glutathione and acetaminophen-cysteine conjugates was developed. The octadecyl silica gel column has been used together with the gradient elution of methanol/water for fast separation of metabolites in less than four minutes. Tandem mass spectrometry in multiple reaction monitoring mode was applied for identification and quantitation of metabolites using deuterated acetaminophen as the internal standard. (en)
Title
  • Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites
  • Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites (en)
skos:prefLabel
  • Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites
  • Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites (en)
skos:notation
  • RIV/00216275:25310/13:39896543!RIV14-MZ0-25310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NT14320), S
http://linked.open...iv/cisloPeriodika
  • s3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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  • 69144
http://linked.open...ai/riv/idVysledku
  • RIV/00216275:25310/13:39896543
http://linked.open...riv/jazykVysledku
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  • porous shell columns; tandem mass spectrometry; liquid chromatography; acetaminophen-glutathione conjugate; acetaminophen (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [F71144BF7BD2]
http://linked.open...i/riv/nazevZdroje
  • Chemické listy S
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 107
http://linked.open...iv/tvurceVysledku
  • Fischer, Jan
  • Nýdlová, Erika
  • Roušar, Tomáš
  • Česla, Petr
  • Česlová, Lenka
  • Vrbová, Martina
issn
  • 1803-2389
number of pages
http://localhost/t...ganizacniJednotka
  • 25310
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