About: Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

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About: Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The intramolecularly coordinated phosphine and stibine ligands L1PPh2 (1), L2PPh2 (2) and L2SbPh2 (3) containing Y,C,Y-chelating ligands, L1?=?2,6-(tBuOCH2)2C6H4- and L2?=?2,6-(Me2NCH2)2C6H4-, were prepared and characterized. The treatment of these ligands 13 with PtCl2 yielded complexes trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), and cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6) as the result of different ability of the starting compounds 13 to complex platinum centre. Compounds 16 were characterized by 1H, 13C and 31P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 36 were determined by X-ray diffraction analysis. The substitution reactions of complexes 46 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me2NCH2)2C6H3]PPh2}PtI2 (7) and {[2,6-(Me2NCH2)2C6H3]SbPh2}PtI2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cisplatin, complex {{[2-(Me2NCH2)-6-(Me2NHCH2)C6H3]PPh2}PtCl2}+Cl- (9) was prepared as water-soluble platinum complex. The cytotoxic effect of complex 9 was evaluated. The intramolecularly coordinated phosphine and stibine ligands L1PPh2 (1), L2PPh2 (2) and L2SbPh2 (3) containing Y,C,Y-chelating ligands, L1?=?2,6-(tBuOCH2)2C6H4- and L2?=?2,6-(Me2NCH2)2C6H4-, were prepared and characterized. The treatment of these ligands 13 with PtCl2 yielded complexes trans-{[2,6-(tBuOCH2)2C6H3]PPh2}2PtCl2 (4), cis-{[2,6-(Me2NCH2)2C6H3]PPh2}PtCl2 (5), and cis-{[2,6-(Me2NCH2)2C6H3]SbPh2}PtCl2 (6) as the result of different ability of the starting compounds 13 to complex platinum centre. Compounds 16 were characterized by 1H, 13C and 31P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 36 were determined by X-ray diffraction analysis. The substitution reactions of complexes 46 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me2NCH2)2C6H3]PPh2}PtI2 (7) and {[2,6-(Me2NCH2)2C6H3]SbPh2}PtI2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cisplatin, complex {{[2-(Me2NCH2)-6-(Me2NHCH2)C6H3]PPh2}PtCl2}+Cl- (9) was prepared as water-soluble platinum complex. The cytotoxic effect of complex 9 was evaluated. (en)
Title	Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands (en)
skos:prefLabel	Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands Synthesis and Cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands (en)
skos:notation	RIV/00216275:25310/12:39895562!RIV13-GA0-25310___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP207/10/0215), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vinklárek, Jaromír Dostál, Libor Růžička, Aleš Jambor, Roman Řezníček, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	172928
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/12:39895562
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytotoxic study; biological tests; chelates; platinum; Y-ligands; C; Y (en)
http://linked.open.../riv/klicoveSlovo	Y platinum chelates C Y-ligands biological tests cytotoxic study
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1532D8F717F7]
http://linked.open...i/riv/nazevZdroje	Applied Organometallic Chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure, Properties and the Use of C,N-, Y,C,Y-chelated Organometallic and Related Metal Complexes
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Dostál, Libor Jambor, Roman Růžička, Aleš Vinklárek, Jaromír Řezáčová, Martina Řezníček, Tomáš
http://linked.open...ain/vavai/riv/wos	000303042800006
issn	0268-2605
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/aoc.2845
http://localhost/t...ganizacniJednotka	25310

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