About: High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet     Goto   Sponge   NotDistinct   Permalink

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  • Context: Increased hepatic de novo lipogenesis(DNL) in response to dietary sugar is implicated in the pathology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation. Methods: In 20 healthy subjects (eight females and 12 males, aged 30.5 +/- 2.0 yr, body mass index 25.9 +/- 0.5 kg/m2) who received a 4-wk lipogenic diet supplemented with 150 g/d of monosaccharides, hepatic SCD1 activity a DNL were determined using validated fatty acid ratios (16:1n-7/16:0; 16:0/18:2n-6) in very low-density lipoprotein triglycerides. Liver fat content was measured by localized 1H-magnetic resonance spectroscopy. Results: At baseline, liver fat content was positively associated with the DNL (r=0.54, P=0.01) but not the SCD1 activity index (r=0.16, P=0.49). Dietary sugar supplementation increased liver fat content and DNL and SCD1 indices (+33, +19, and +8%, respectively). The increase of the DNL index was strongly related to the changes in liver fat content during the sugar supplementation (r=0.75, P=0.0001) but showed no association with changes in the SCD1 activity (P greater than 0.35). After the monosaccharide supplementation, the DNL index was still positively associated with liver fat content (r=0.52, P=0.02), whereas SCD1 activity showed a strong negative correlation with liver fat content (r=-0.63, P=0.002). Conclusions: DNL is closely linked with hepatic steatosis under dietary conditions rich in monosaccharides. Our data suggest that the individual hepatic SCD1 activity is a determinant of liver fat accumulation under lipogenic dietary conditions.
  • Context: Increased hepatic de novo lipogenesis(DNL) in response to dietary sugar is implicated in the pathology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation of fatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation. Methods: In 20 healthy subjects (eight females and 12 males, aged 30.5 +/- 2.0 yr, body mass index 25.9 +/- 0.5 kg/m2) who received a 4-wk lipogenic diet supplemented with 150 g/d of monosaccharides, hepatic SCD1 activity a DNL were determined using validated fatty acid ratios (16:1n-7/16:0; 16:0/18:2n-6) in very low-density lipoprotein triglycerides. Liver fat content was measured by localized 1H-magnetic resonance spectroscopy. Results: At baseline, liver fat content was positively associated with the DNL (r=0.54, P=0.01) but not the SCD1 activity index (r=0.16, P=0.49). Dietary sugar supplementation increased liver fat content and DNL and SCD1 indices (+33, +19, and +8%, respectively). The increase of the DNL index was strongly related to the changes in liver fat content during the sugar supplementation (r=0.75, P=0.0001) but showed no association with changes in the SCD1 activity (P greater than 0.35). After the monosaccharide supplementation, the DNL index was still positively associated with liver fat content (r=0.52, P=0.02), whereas SCD1 activity showed a strong negative correlation with liver fat content (r=-0.63, P=0.002). Conclusions: DNL is closely linked with hepatic steatosis under dietary conditions rich in monosaccharides. Our data suggest that the individual hepatic SCD1 activity is a determinant of liver fat accumulation under lipogenic dietary conditions. (en)
Title
  • High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
  • High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet (en)
skos:prefLabel
  • High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
  • High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet (en)
skos:notation
  • RIV/00216275:25310/12:39895013!RIV13-MSM-25310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, S
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 138929
http://linked.open...ai/riv/idVysledku
  • RIV/00216275:25310/12:39895013
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hepatic steatosis; desaturation; saturated fatty acid; de novo lipogenesis; liver fat; activity index; hepatic SCD1 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [793EAC0B9B22]
http://linked.open...i/riv/nazevZdroje
  • Journal of Clinical Endocrinology and Metabolism
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 97
http://linked.open...iv/tvurceVysledku
  • Peter, Andreas
  • Stefan, Norbert
  • Čegan, Alexander
  • Kovářová, Markéta
  • Schleicher, Erwin
  • Fritsche, Andreas
  • Haering, Hans-Ulrich
  • Lehmann, Rainer
  • Machann, Juergen
  • Schick, Fritz
  • Silbernagel, Guenther
http://linked.open...ain/vavai/riv/wos
  • 000312003900012
issn
  • 0021-972X
number of pages
http://bibframe.org/vocab/doi
  • 10.1210/jc.2012-2152
http://localhost/t...ganizacniJednotka
  • 25310
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