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  • Two-dimensional (2D) LC-LC separation techniques can be used to significantly increase the number of compounds separated in a single run in comparison with single-dimension separations and to classify a sample on the basis of structural similarities. In-line %22comprehensive%22 LC x LC has experienced a rapid development over the past years, because it allows automatic performance avoiding tedious and time-consuming off-line fraction transfer between the separation systems. Combining different LC separation mechanisms, such as reversed-phase (RP), ionexchange (IEX) and normal-phase (NP) or HILIC chromatography is aimed to accomplish a non-correlated retention with the maximum peak capacity in the time available for the analysis in %22orthogonal%22 two-dimensional LC x LC separation systems.
  • Two-dimensional (2D) LC-LC separation techniques can be used to significantly increase the number of compounds separated in a single run in comparison with single-dimension separations and to classify a sample on the basis of structural similarities. In-line %22comprehensive%22 LC x LC has experienced a rapid development over the past years, because it allows automatic performance avoiding tedious and time-consuming off-line fraction transfer between the separation systems. Combining different LC separation mechanisms, such as reversed-phase (RP), ionexchange (IEX) and normal-phase (NP) or HILIC chromatography is aimed to accomplish a non-correlated retention with the maximum peak capacity in the time available for the analysis in %22orthogonal%22 two-dimensional LC x LC separation systems. (en)
Title
  • Advantages of two-dimensional liquid chromatography in the analysis of complex samples
  • Advantages of two-dimensional liquid chromatography in the analysis of complex samples (en)
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  • Advantages of two-dimensional liquid chromatography in the analysis of complex samples
  • Advantages of two-dimensional liquid chromatography in the analysis of complex samples (en)
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  • RIV/00216275:25310/11:39892641!RIV12-GA0-25310___
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  • P(GA203/07/0641), Z(MSM0021627502)
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  • 3
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  • 184773
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  • RIV/00216275:25310/11:39892641
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  • Gradient elution; Comprehensive LC x LC; Two-dimensional LC (en)
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  • LT - Litevská republika
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  • 22
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  • Hájek, Tomáš
  • Jandera, Pavel
  • Česla, Petr
  • Škeříková, Veronika
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  • 0235-7216
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  • 25310
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