About: Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data

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About: Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Capecitabine has been studied by a combined potentiometric and spectrophotometric titration at T = (298.15, 310.15) K at different ionic strengths. The thermodynamic dissociation constant was estimated by non-linear regression of (pK(a), I) data: pK(a)(T) = 8.97(1) at T = 298.15 K and pK(a)(T) = 8.74(0) at T = 310.15 K, where the figure in the brackets is the standard deviation in last significant digits. Thermodynamic parameters Delta H degrees/kJ.mol(-1) and Delta S degrees/J.K-1.mol(-1) have been determined from the temperature variation of thermodynamic dissociation constants. The value of enthalpy Delta H degrees = 33.9 kJ.mol(-1) shows the dissociation process is endothermic and the value of entropy Delta S degrees = -51.9J.K-1.mol(-1) indicates that the dissociation is not a spontaneous process. Capecitabine has been studied by a combined potentiometric and spectrophotometric titration at T = (298.15, 310.15) K at different ionic strengths. The thermodynamic dissociation constant was estimated by non-linear regression of (pK(a), I) data: pK(a)(T) = 8.97(1) at T = 298.15 K and pK(a)(T) = 8.74(0) at T = 310.15 K, where the figure in the brackets is the standard deviation in last significant digits. Thermodynamic parameters Delta H degrees/kJ.mol(-1) and Delta S degrees/J.K-1.mol(-1) have been determined from the temperature variation of thermodynamic dissociation constants. The value of enthalpy Delta H degrees = 33.9 kJ.mol(-1) shows the dissociation process is endothermic and the value of entropy Delta S degrees = -51.9J.K-1.mol(-1) indicates that the dissociation is not a spontaneous process. (en)
Title	Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data (en)
skos:prefLabel	Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data (en)
skos:notation	RIV/00216275:25310/11:39883426!RIV12-MZ0-25310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS9831), Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Ferenčíková, Zuzana Meloun, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	193914
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/11:39883426
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HYPERQUAD; ESAB2M; SQUAD; SPECFIT; Capecitabine; Dissociation constant; Potentiometric titration; Spectrophotometric titration (en)
http://linked.open.../riv/klicoveSlovo	Capecitabine Dissociation constant ESAB2M HYPERQUAD Potentiometric titration SPECFIT SQUAD Spectrophotometric titration
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0854D52DE9B4]
http://linked.open...i/riv/nazevZdroje	Journal of Chemical Thermodynamics
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Optimization of laboratory examinations in endocrinology using multivariate statistics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Ferenčíková, Zuzana Meloun, Milan Vrána, Aleš
http://linked.open...ain/vavai/riv/wos	000289600400013
http://linked.open...n/vavai/riv/zamer	Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	0021-9614
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jct.2011.01.012
http://localhost/t...ganizacniJednotka	25310

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