About: Glutathione Reductase Is Inhibited by Acetaminophen-glutathione Conjugate in vitro

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About: Glutathione Reductase Is Inhibited by Acetaminophen-glutathione Conjugate in vitro Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified by column chromatography. The inhibitory effect of the conjugate on two types of glutathione reductase (from yeasts and rat hepatocytes) was tested spectrophotometrically. In addition, the enzyme activity (from hepatocytes lysate) was decreased to 79?7 %, 67?2 % and 39?7 %, in 0.37, 1.48 and 3.7 mM concentration of the conjugate, respectively. We ound that glutathione reductase, the essential enzyme of the antioxidant system, was dosedependently inhibited by the product of acetaminophen metabolism - the conjugate of acetaminophen and glutathione. The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified by column chromatography. The inhibitory effect of the conjugate on two types of glutathione reductase (from yeasts and rat hepatocytes) was tested spectrophotometrically. In addition, the enzyme activity (from hepatocytes lysate) was decreased to 79?7 %, 67?2 % and 39?7 %, in 0.37, 1.48 and 3.7 mM concentration of the conjugate, respectively. We ound that glutathione reductase, the essential enzyme of the antioxidant system, was dosedependently inhibited by the product of acetaminophen metabolism - the conjugate of acetaminophen and glutathione. (en)
Title	Glutathione Reductase Is Inhibited by Acetaminophen-glutathione Conjugate in vitro Glutathione Reductase Is Inhibited by Acetaminophen-glutathione Conjugate in vitro (en)
skos:prefLabel	Glutathione Reductase Is Inhibited by Acetaminophen-glutathione Conjugate in vitro Glutathione Reductase Is Inhibited by Acetaminophen-glutathione Conjugate in vitro (en)
skos:notation	RIV/00216275:25310/10:39883232!RIV11-MSM-25310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620820), Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Roušar, Tomáš Bartoš, Martin Pařík, Patrik
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	260845
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39883232
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hepatotoxicity; glutathione; glutathione reductase; Acetaminophen toxicity (en)
http://linked.open.../riv/klicoveSlovo	glutathione reductase hepatotoxicity Acetaminophen toxicity glutathione
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B37F77D01329]
http://linked.open...i/riv/nazevZdroje	Physiological Reasearch
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Pařík, Patrik Roušar, Tomáš Bartoš, Martin Kučera, Otto Červinková, Zuzana
http://linked.open...ain/vavai/riv/wos	000278016200009
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	0862-8408
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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