About: Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis an intracellular microorganism

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About: Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis an intracellular microorganism Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Despite the recent identification of novel virulence factors, the mechanisms of virulence in Francisella tularensis are poorly understood. In spite of its importance, questions about glycosylation of proteins in this bacterium and its potential connection with bacterial virulence have not been answered yet. In the present study, several putative Francisella tularensis glycoproteins were characterized through the combination of carbohydrate-specific detection and lectin affinity with mass spectrometry. The protein PilA that was recently found as being possibly glycosylated, as well as other proteins with designation as novel factors of virulence, was among the proteins identified in this study. The reported data compile the list of potential glycoproteins that may serve as a take-off platform for a further definition of proteins modified by glycans, faciliting a better understanding of the function of protein glycosylation in pathogenicity of Francisella tularensis. Despite the recent identification of novel virulence factors, the mechanisms of virulence in Francisella tularensis are poorly understood. In spite of its importance, questions about glycosylation of proteins in this bacterium and its potential connection with bacterial virulence have not been answered yet. In the present study, several putative Francisella tularensis glycoproteins were characterized through the combination of carbohydrate-specific detection and lectin affinity with mass spectrometry. The protein PilA that was recently found as being possibly glycosylated, as well as other proteins with designation as novel factors of virulence, was among the proteins identified in this study. The reported data compile the list of potential glycoproteins that may serve as a take-off platform for a further definition of proteins modified by glycans, faciliting a better understanding of the function of protein glycosylation in pathogenicity of Francisella tularensis. (en)
Title	Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis an intracellular microorganism Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis an intracellular microorganism (en)
skos:prefLabel	Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis an intracellular microorganism Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis an intracellular microorganism (en)
skos:notation	RIV/00216275:25310/10:39881730!RIV12-GA0-25310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/0857), P(ME08105), P(OVUOFVZ200808), Z(MO0FVZ0000604), Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bílková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	273139
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39881730
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mass spectrometry; glycoproteins; Francisella tularensis (en)
http://linked.open.../riv/klicoveSlovo	glycoproteins mass spectrometry Francisella tularensis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[93FFEE5B6899]
http://linked.open...i/riv/nazevZdroje	Journal of Proteome Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Differential proteome analysis of bacterial Francisella tularensis glyco- and phospho- proteins Development of new prophylactic tools against Francisella tularensis infection New analytical approaches for identification of proteins with significant attributes for virulence and pathogenity of bacteria
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Balonová, Lucie Hernychová, Lenka Stulík, Jiří Bílková, Zuzana Link, Marek Mann, Benjamin F. Novotný, Miloš. V.
http://linked.open...ain/vavai/riv/wos	000276215700035
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	1535-3893
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/pr9011602
http://localhost/t...ganizacniJednotka	25310

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