About: The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data ,

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About: The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data , Goto Sponge NotDistinct Permalink

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Description	The mixed dissociation constants of rasagiline-free base [N-propargyl-1-(R)aminoindan] and rasagiline mesylate [N-propargyl-1-(R)aminoindan] methansulfonate) at different ionic strengths I in the range of (0.01 and 0.4) mol . L-1 and at temperatures of (25 and 37) degrees C were determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECEIT32 and SQUAD(84), nonlinear regression analyses. Most indices always predict the correct number of components when the signal-to-error ratio (SER) is higher than 10: for rasagiline base, pK(a)(T) = 7.12(1) at 25 degrees C and 7.01(1) at 37 degrees C; for rasagiline mesylate, pK(a)(T) = 7.07(1) at 25 degrees C and 7.16(1) at 37 degrees C, where the value in parentheses is the standard deviation in the last significant digit. The mixed dissociation constants of rasagiline-free base [N-propargyl-1-(R)aminoindan] and rasagiline mesylate [N-propargyl-1-(R)aminoindan] methansulfonate) at different ionic strengths I in the range of (0.01 and 0.4) mol . L-1 and at temperatures of (25 and 37) degrees C were determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECEIT32 and SQUAD(84), nonlinear regression analyses. Most indices always predict the correct number of components when the signal-to-error ratio (SER) is higher than 10: for rasagiline base, pK(a)(T) = 7.12(1) at 25 degrees C and 7.01(1) at 37 degrees C; for rasagiline mesylate, pK(a)(T) = 7.07(1) at 25 degrees C and 7.16(1) at 37 degrees C, where the value in parentheses is the standard deviation in the last significant digit. (en)
Title	The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data , The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data , (en)
skos:prefLabel	The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data , The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data , (en)
skos:notation	RIV/00216275:25310/10:39881671!RIV11-MZ0-25310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(NR9055), P(NS9831), S, Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Meloun, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	292758
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39881671
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	programs; computation; pk(a); drugs; B inhibitor; stability-constants; multicomponent spectra; parkinsons-disease; spectroscopic data; Equilibrium constants (en)
http://linked.open.../riv/klicoveSlovo	B inhibitor multicomponent spectra pk(a) spectroscopic data computation stability-constants drugs programs parkinsons-disease Equilibrium constants
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2D9D4207EEE4]
http://linked.open...i/riv/nazevZdroje	Journal of Chemical and Engineering Data
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Optimization of laboratory examinations in endocrinology using multivariate statistics Influence of smoking and its cessation on endocrine system
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Ferenčíková, Zuzana Meloun, Milan Vrána, Aleš
http://linked.open...ain/vavai/riv/wos	000280727300010
http://linked.open...n/vavai/riv/zamer	Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	0021-9568
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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