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rdf:type
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Description
| - The mixed dissociation constants of methotrexate - chemically (2S)-2-[(4-{[(2,4-diamino-7,8-dihydropteridin-6-yl) methyl] (methyl) amino} phenyl) formamido] pentanedioic acid (the cas number 59-05-2) at various ionic strengths I of range 0.01 - 0.4, and at temperatures of 25 degrees C and 37 degrees C, were determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECFIT32 and SQUAD(84) nonlinear regression analyses and INDICES factor analysis. Three thermodynamic dissociation constants were estimated by nonlinear regression of {pK(a), I} data: for methotrexate pK(a1)(T) = 2.895(13), pK(a2)(T) = 4.410(14), pK(a3)(T) = 5.726(15) at 25 degrees C and pK(a1)(T) = 3.089(15), pK(a2)(T) = 4.392(12), pK(a3)(T) = 5.585(11) at 37 degrees C.
- The mixed dissociation constants of methotrexate - chemically (2S)-2-[(4-{[(2,4-diamino-7,8-dihydropteridin-6-yl) methyl] (methyl) amino} phenyl) formamido] pentanedioic acid (the cas number 59-05-2) at various ionic strengths I of range 0.01 - 0.4, and at temperatures of 25 degrees C and 37 degrees C, were determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECFIT32 and SQUAD(84) nonlinear regression analyses and INDICES factor analysis. Three thermodynamic dissociation constants were estimated by nonlinear regression of {pK(a), I} data: for methotrexate pK(a1)(T) = 2.895(13), pK(a2)(T) = 4.410(14), pK(a3)(T) = 5.726(15) at 25 degrees C and pK(a1)(T) = 3.089(15), pK(a2)(T) = 4.392(12), pK(a3)(T) = 5.585(11) at 37 degrees C. (en)
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Title
| - The thermodynamic dissociation constants of methotrexate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data
- The thermodynamic dissociation constants of methotrexate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data (en)
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skos:prefLabel
| - The thermodynamic dissociation constants of methotrexate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data
- The thermodynamic dissociation constants of methotrexate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data (en)
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skos:notation
| - RIV/00216275:25310/10:39881670!RIV11-MZ0-25310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(NR9055), P(NS9831), S, Z(MSM0021627502)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/10:39881670
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - INDICES; Squad; Specfit; Methotrexate; Dissociation constant; Spectrophotometric titration (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Central European Journal of Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Ferenčíková, Zuzana
- Meloun, Milan
- Vrána, Aleš
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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