About: Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates

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About: Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Homological series of 14 nonchiral derivates and series of 5 chiral derivates of imidazole were tested in vitro as inhibitors of hydrolysis of acetylcholine using enzyme preparation of acetylcholine esterase from electric eel. The batch stirred reactor at 25°C, pH 8 (phosphate buffer), ionic strength 0.11 M and catalytic activity of the enzyme preparation 0.14 U ml-1 of the reaction mixture were used. The temporal dependences of actual concentrations of acetylcholine, choline and acetic acid were determined by an original HPLC method. For all used inhibitors, these time dependences conform with the probability of more than 90 % to the model of competitive irreversible inhibition. All kinetic constants including k3 defining the rate of inhibition (0.71 - 5.3 M-1 s-1) and qualified estimation of the absolute acetylcholine esterase concentration in the reaction mixture (40 - 110 nM) were determined. Homological series of 14 nonchiral derivates and series of 5 chiral derivates of imidazole were tested in vitro as inhibitors of hydrolysis of acetylcholine using enzyme preparation of acetylcholine esterase from electric eel. The batch stirred reactor at 25°C, pH 8 (phosphate buffer), ionic strength 0.11 M and catalytic activity of the enzyme preparation 0.14 U ml-1 of the reaction mixture were used. The temporal dependences of actual concentrations of acetylcholine, choline and acetic acid were determined by an original HPLC method. For all used inhibitors, these time dependences conform with the probability of more than 90 % to the model of competitive irreversible inhibition. All kinetic constants including k3 defining the rate of inhibition (0.71 - 5.3 M-1 s-1) and qualified estimation of the absolute acetylcholine esterase concentration in the reaction mixture (40 - 110 nM) were determined. (en)
Title	Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates (en)
skos:prefLabel	Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates (en)
skos:notation	RIV/00216275:25310/10:39881510!RIV11-MSM-25310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Čegan, Alexander Komers, Karel Kovářová, Markéta Štěpánková, Šárka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	263998
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39881510
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chiral; achiral; imidazoles; inhibition; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo	imidazoles chiral inhibition achiral acetylcholinesterase
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[0855AD0EA5B7]
http://linked.open...i/riv/nazevZdroje	Bioresource Technology
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	101
http://linked.open...iv/tvurceVysledku	Čegan, Alexander Komers, Karel Kovářová, Markéta Štěpánková, Šárka
http://linked.open...ain/vavai/riv/wos	000278035900080
http://linked.open...n/vavai/riv/zamer	Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	0960-8524
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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