About: Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

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About: Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polyphenolic compounds occurring in hop extracts and their phases I and II metabolites formed during in vivo rat biotransformation have been analyzed using HPLC/MS/MS with electrospray ionization and QqTOF analyzer. Both ESI polarity modes are used for the determination of molecular weights in the full scan spectra and the structural information in subsequent tandem mass spectra. The emphasis is given on the elemental composition determination of individual metabolites based on accurate masses typically better than 5 ppm even with the external calibration. Advanced software tools are used for the metabolite identification using the comparison of the blank chromatogram with the real incubation sample together with the software prediction and detection of possible metabolites. More than ten compounds originating from the hops are identified in rat feces, two of them belong to phase I metabolites and five compounds are phase II metabolites. Polyphenolic compounds occurring in hop extracts and their phases I and II metabolites formed during in vivo rat biotransformation have been analyzed using HPLC/MS/MS with electrospray ionization and QqTOF analyzer. Both ESI polarity modes are used for the determination of molecular weights in the full scan spectra and the structural information in subsequent tandem mass spectra. The emphasis is given on the elemental composition determination of individual metabolites based on accurate masses typically better than 5 ppm even with the external calibration. Advanced software tools are used for the metabolite identification using the comparison of the blank chromatogram with the real incubation sample together with the software prediction and detection of possible metabolites. More than ten compounds originating from the hops are identified in rat feces, two of them belong to phase I metabolites and five compounds are phase II metabolites. (en)
Title	Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (en)
skos:prefLabel	Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (en)
skos:notation	RIV/00216275:25310/10:39881357!RIV11-GA0-25310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/08/1536), Z(MSM0021627502), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	25
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Holčapek, Michal Jirásko, Robert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	262711
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39881357
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPLC/MS/MS; Phenolic compounds; Sulfate; Metabolites; Hop; Xanthohumol (en)
http://linked.open.../riv/klicoveSlovo	Hop Metabolites Xanthohumol Sulfate Phenolic compounds HPLC/MS/MS
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CE448FE681BA]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Progressive methods in chemical, food and clinical analysis
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	1217
http://linked.open...iv/tvurceVysledku	Holčapek, Michal Ulrichová, Jitka Šimánek, Vilím Jirásko, Robert Vrublová, Eva
http://linked.open...ain/vavai/riv/wos	000278779000018
http://linked.open...n/vavai/riv/zamer	Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0021-9673
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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