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rdf:type
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Description
| - Kinetic evidence has indicated that methanolysis of synthesized 4-acetoxybenzyl carbamates proceeds via a one-step (concerted) mechanism. Concerted 1,6-elimination produces the very reactive 1,4-quinonemethide, which was trapped in the form of 4-methoxymethylphenol. The inhibition activity of benzyl N-phenylcarbamates to acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) was also tested. The found IC50 values varied within the limits of 199-535 mu mol.l(-1) for ACHE and 21-177 mu mol.l(-1) for BCHE. The found values of partition coefficient (P-ow) in the range of 1.5-11.5 represent a prerequisite of good transport of benzyl N-phenylcarbamates through haemato-encephalic barrier.
- Kinetic evidence has indicated that methanolysis of synthesized 4-acetoxybenzyl carbamates proceeds via a one-step (concerted) mechanism. Concerted 1,6-elimination produces the very reactive 1,4-quinonemethide, which was trapped in the form of 4-methoxymethylphenol. The inhibition activity of benzyl N-phenylcarbamates to acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) was also tested. The found IC50 values varied within the limits of 199-535 mu mol.l(-1) for ACHE and 21-177 mu mol.l(-1) for BCHE. The found values of partition coefficient (P-ow) in the range of 1.5-11.5 represent a prerequisite of good transport of benzyl N-phenylcarbamates through haemato-encephalic barrier. (en)
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Title
| - Substituted benzyl N-phenylcarbamates - their solvolysis and inhibition activity to acetylcholinesterase and butyrylcholinesterase
- Substituted benzyl N-phenylcarbamates - their solvolysis and inhibition activity to acetylcholinesterase and butyrylcholinesterase (en)
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skos:prefLabel
| - Substituted benzyl N-phenylcarbamates - their solvolysis and inhibition activity to acetylcholinesterase and butyrylcholinesterase
- Substituted benzyl N-phenylcarbamates - their solvolysis and inhibition activity to acetylcholinesterase and butyrylcholinesterase (en)
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skos:notation
| - RIV/00216275:25310/09:00008364!RIV10-MSM-25310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - Z(MSM0021627501), Z(MSM0021627502)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/09:00008364
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - carbamates; acetylcholinesterase; 1; 4-quinonemethide; inhibition (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Drabina, Pavel
- Sedlák, Miloš
- Čegan, Alexander
- Hanusek, Jiří
- Štěpánková, Šárka
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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