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| Description
| - Alzheimer´s disease is the most common neurodegenerative disorder, clinically characterized by a noticeable cognitive decline defined by a loss of memory and learning ability, together with a reduced ability to perform basic activities of daily living, and a diverse array of neuropsychiatric symptoms such as apathy, verbal and physical agitation, irritability, depression etc. Pharmacotherapy of Alzheimer´s disease has progressed in the past ten years from the use of psychotropic medications for sedation to the use of rational treatments aimed at neurotransmitter replacement. Only one class of medications has been extensively evaluated in clinical trials with patients with Alzheimer´s disease and is approved by the US Food and Drug Administration for Alzheimer´s disease treatment. These medications are cholinesterase inhibitors and have a significant, although modest, effect on the cognitive status of patients with Alzheimer´s disease.
- Alzheimer´s disease is the most common neurodegenerative disorder, clinically characterized by a noticeable cognitive decline defined by a loss of memory and learning ability, together with a reduced ability to perform basic activities of daily living, and a diverse array of neuropsychiatric symptoms such as apathy, verbal and physical agitation, irritability, depression etc. Pharmacotherapy of Alzheimer´s disease has progressed in the past ten years from the use of psychotropic medications for sedation to the use of rational treatments aimed at neurotransmitter replacement. Only one class of medications has been extensively evaluated in clinical trials with patients with Alzheimer´s disease and is approved by the US Food and Drug Administration for Alzheimer´s disease treatment. These medications are cholinesterase inhibitors and have a significant, although modest, effect on the cognitive status of patients with Alzheimer´s disease. (en)
- Alzheimerova choroba je nejběžnější neurodegenerativní onemocnění klinicky charakterizované významným poklesem kognitivních funkcí, ztrátou paměti a schopnosti se učit, společně s poklesem schopnosti vykonávat běžné denní aktivity. Významnými neuropsychiatrickými symptomy jsou apatie, podrážděnost, deprese atd. Farmakoterapie Alzheimerovy choroby se za posledních deset let posunula od užívání psychotropních léčiv na uklidnění k léčivům zaměřeným na náhradu neurotransmiterů. Jenom jedna skupina léčiv byla rozsáhle hodnocena v klinických studiích s pacienty s Alzheimerovou chorobou a schválena FDA pro léčbu Alzheimerovy choroby. Jsou to inhibitory cholinesteráz, které mají významný vliv na stav kognitivních funkcí u pacientů s Alzheimerovou chorobou. (cs)
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| Title
| - Cholinesterases and Cholinesterase Inhibitors
- Cholinesterases and Cholinesterase Inhibitors (en)
- Cholinesterázy a cholinesterázové inhibitory (cs)
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| skos:prefLabel
| - Cholinesterases and Cholinesterase Inhibitors
- Cholinesterases and Cholinesterase Inhibitors (en)
- Cholinesterázy a cholinesterázové inhibitory (cs)
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| skos:notation
| - RIV/00216275:25310/08:00007777!RIV09-MSM-25310___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/08:00007777
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Alzheimer´s disease; cholinesterases; cholinesterase inhibitors (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Current Enzyme Inhibition
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Komers, Karel
- Štěpánková, Šárka
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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