| Attributes | Values |
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| rdf:type
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| Description
| - In positron emission tomography (PET) a-methyl amino acids have two potential applications: As analogues of neutransmitter precursors for the study of neurodegenerative diseases, and as non-metabolised analogues of proteinogenic amino acids for the study of amino acid uptake into normal and cancer cells. Clinical applications of such amino acids are strongly limited due to their poor availability. We carried out [11C]methylation of metalocomplex synthons derived from protected DOPA or tyrosine. For [11C]methylation, sodium hydroxide (5mg of fine dry powder) was sealed in a vial, which was flushed with dry nitrogen before addition of a solution of the complex (10 mg) and 11CH3I in 1,3-dimethylimidazolidin-2-one (300 ml). After 10 min at 258C, a 9% radiochemical yield (decay-corrected) of a mixture of the diastereomeric a-[11C]methylDOPA complexes or a 7% radiochemical yield of a mixture of the diastereomeric a-[11C]methyltyrosine complexes was achieved. Individual diastereomers were successfully sepa
- In positron emission tomography (PET) a-methyl amino acids have two potential applications: As analogues of neutransmitter precursors for the study of neurodegenerative diseases, and as non-metabolised analogues of proteinogenic amino acids for the study of amino acid uptake into normal and cancer cells. Clinical applications of such amino acids are strongly limited due to their poor availability. We carried out [11C]methylation of metalocomplex synthons derived from protected DOPA or tyrosine. For [11C]methylation, sodium hydroxide (5mg of fine dry powder) was sealed in a vial, which was flushed with dry nitrogen before addition of a solution of the complex (10 mg) and 11CH3I in 1,3-dimethylimidazolidin-2-one (300 ml). After 10 min at 258C, a 9% radiochemical yield (decay-corrected) of a mixture of the diastereomeric a-[11C]methylDOPA complexes or a 7% radiochemical yield of a mixture of the diastereomeric a-[11C]methyltyrosine complexes was achieved. Individual diastereomers were successfully sepa (en)
- In positron emission tomography (PET) a-methyl amino acids have two potential applications: As analogues of neutransmitter precursors for the study of neurodegenerative diseases, and as non-metabolised analogues of proteinogenic amino acids for the study of amino acid uptake into normal and cancer cells. Clinical applications of such amino acids are strongly limited due to their poor availability. We carried out [11C]methylation of metalocomplex synthons derived from protected DOPA or tyrosine. For [11C]methylation, sodium hydroxide (5mg of fine dry powder) was sealed in a vial, which was flushed with dry nitrogen before addition of a solution of the complex (10 mg) and 11CH3I in 1,3-dimethylimidazolidin-2-one (300 ml). After 10 min at 258C, a 9% radiochemical yield (decay-corrected) of a mixture of the diastereomeric a-[11C]methylDOPA complexes or a 7% radiochemical yield of a mixture of the diastereomeric a-[11C]methyltyrosine complexes was achieved. Individual diastereomers were successfully sepa (cs)
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| Title
| - Towards stereoselective radiosynthesis of α-[11C]methylsubtituted aromatic α-amino acids ? a challenge of creation of quaternary asymmetric centre in a very short time.
- Towards stereoselective radiosynthesis of α-[11C]methylsubtituted aromatic α-amino acids ? a challenge of creation of quaternary asymmetric centre in a very short time. (en)
- Towards stereoselective radiosynthesis of α-[11C]methylsubtituted aromatic α-amino acids ? a challenge of creation of quaternary asymmetric centre in a very short time. (cs)
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| skos:prefLabel
| - Towards stereoselective radiosynthesis of α-[11C]methylsubtituted aromatic α-amino acids ? a challenge of creation of quaternary asymmetric centre in a very short time.
- Towards stereoselective radiosynthesis of α-[11C]methylsubtituted aromatic α-amino acids ? a challenge of creation of quaternary asymmetric centre in a very short time. (en)
- Towards stereoselective radiosynthesis of α-[11C]methylsubtituted aromatic α-amino acids ? a challenge of creation of quaternary asymmetric centre in a very short time. (cs)
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| skos:notation
| - RIV/00216275:25310/07:00006287!RIV08-MSM-25310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/07:00006287
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - asymetris synthesis; a-methyl amino acids; carbon-11; [11C]methylation; DOPA; tyrosine; nickel; complexes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Labelled Compounds and Radiopharmaceuticals
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Lyčka, Antonín
- Nádvorník, Milan
- Kružberská, Pavla
- Popkov, Alexandr
- Gillings, Nicholas
- Lehel, Szabolcs
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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