About: Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too. Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too. (en) Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too. (cs)
Title	Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy Utilization of HPLC for monitoring of less-known risk factors of atherosclerosis (en) Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy (cs)
skos:prefLabel	Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy Utilization of HPLC for monitoring of less-known risk factors of atherosclerosis (en) Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy (cs)
skos:notation	RIV/00216275:25310/06:00003176!RIV08-MSM-25310___
http://linked.open.../vavai/riv/strany	8-9
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kanďár, Roman Žáková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	507908
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/06:00003176
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	atherosclerosis; homocysteine; coenzyme Q10; HPLC; coulometric electrochemical detection (en)
http://linked.open.../riv/klicoveSlovo	homocysteine coulometric electrochemical detection HPLC atherosclerosis coenzyme Q10
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2D867DE3BB77]
http://linked.open...i/riv/nazevZdroje	CHEMagazín
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Kanďár, Roman Žáková, Pavla
http://linked.open...n/vavai/riv/zamer	Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	1210-7409
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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