About: 2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles:Synthesis and Reactions     Goto   Sponge   NotDistinct   Permalink

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  • The synthesis and reactions of methyl 2-[3-(trifluoromethyl)phenyl-4H-furo[3,2-b]pyrrole-5-carboxylate (la) are described. Upon reaction with methyl iodide, benzyl chloride, or acetic anhydride, this compound gave N-substituted products 1b-d. By hydrolysis of compounds la-c, the corresponding acids 2a-c were formed, or by reaction with hydrazine-hydrate, the corresponding carbohydrazides 3a-c were formed. By heating 2-[3-(trifluoromethyl)phenly]-4H-furo[3,2-b]pyrrole-5-carboxylic acid (2a) in acetic anhydride, 4-acetyl-2-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyrrole (4) was formed. By hydrolysis of 4, 2[3-(trifluoromethyl)phenyl-4H-furo[3,2-b]pyrrole (5a) was formed, and reactions with methyl iodide or benzyl chloride gave N-substituted products 5b-c. The reaction of 4 with dimethyl butynedioate gave substituted benzo[b]furan 6. Compound 3a reacted with triethyl orthoesters giving 7a-c, which afforded with phosphorus (V) sulphide the corresponding thiones 8a-c. The thiones 8a-c reacted with hydrazine
  • The synthesis and reactions of methyl 2-[3-(trifluoromethyl)phenyl-4H-furo[3,2-b]pyrrole-5-carboxylate (la) are described. Upon reaction with methyl iodide, benzyl chloride, or acetic anhydride, this compound gave N-substituted products 1b-d. By hydrolysis of compounds la-c, the corresponding acids 2a-c were formed, or by reaction with hydrazine-hydrate, the corresponding carbohydrazides 3a-c were formed. By heating 2-[3-(trifluoromethyl)phenly]-4H-furo[3,2-b]pyrrole-5-carboxylic acid (2a) in acetic anhydride, 4-acetyl-2-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyrrole (4) was formed. By hydrolysis of 4, 2[3-(trifluoromethyl)phenyl-4H-furo[3,2-b]pyrrole (5a) was formed, and reactions with methyl iodide or benzyl chloride gave N-substituted products 5b-c. The reaction of 4 with dimethyl butynedioate gave substituted benzo[b]furan 6. Compound 3a reacted with triethyl orthoesters giving 7a-c, which afforded with phosphorus (V) sulphide the corresponding thiones 8a-c. The thiones 8a-c reacted with hydrazine (en)
  • The synthesis and reactions of methyl 2-[3-(trifluoromethyl)phenyl-4H-furo[3,2-b]pyrrole-5-carboxylate (la) are described. Upon reaction with methyl iodide, benzyl chloride, or acetic anhydride, this compound gave N-substituted products 1b-d. By hydrolysis of compounds la-c, the corresponding acids 2a-c were formed, or by reaction with hydrazine-hydrate, the corresponding carbohydrazides 3a-c were formed. By heating 2-[3-(trifluoromethyl)phenly]-4H-furo[3,2-b]pyrrole-5-carboxylic acid (2a) in acetic anhydride, 4-acetyl-2-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyrrole (4) was formed. By hydrolysis of 4, 2[3-(trifluoromethyl)phenyl-4H-furo[3,2-b]pyrrole (5a) was formed, and reactions with methyl iodide or benzyl chloride gave N-substituted products 5b-c. The reaction of 4 with dimethyl butynedioate gave substituted benzo[b]furan 6. Compound 3a reacted with triethyl orthoesters giving 7a-c, which afforded with phosphorus (V) sulphide the corresponding thiones 8a-c. The thiones 8a-c reacted with hydrazine (cs)
Title
  • 2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles:Synthesis and Reactions
  • 2-[3-(Trifluoromethyl)fenyl]furo[3,2-b]pyrroly:Syntéza a reakce (cs)
  • 2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles:Synthesis and Reactions (en)
skos:prefLabel
  • 2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles:Synthesis and Reactions
  • 2-[3-(Trifluoromethyl)fenyl]furo[3,2-b]pyrroly:Syntéza a reakce (cs)
  • 2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles:Synthesis and Reactions (en)
skos:notation
  • RIV/00216275:25310/05:00002720!RIV08-MSM-25310___
http://linked.open.../vavai/riv/strany
  • 311-325
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021627501)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 552690
http://linked.open...ai/riv/idVysledku
  • RIV/00216275:25310/05:00002720
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • 2-[3-(trifluoromethyl)phenyl]furo[3,2-bjpyrroles; hydrazides; hydrazones; cycloaddition; condensation; phase transfer catalysis; microwave irradiation; H-1 and C-13 NMR spectra (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • PL - Polská republika
http://linked.open...ontrolniKodProRIV
  • [54F5273A9DF9]
http://linked.open...i/riv/nazevZdroje
  • Central European Journal of Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 3
http://linked.open...iv/tvurceVysledku
  • Bureš, Filip
  • Gajdoš, Peter
  • Krutošíková, Alžbeta
  • Pavlíková, Soňa
http://linked.open...n/vavai/riv/zamer
issn
  • 1644-3624
number of pages
http://localhost/t...ganizacniJednotka
  • 25310
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