About: Half-inhibition concentrations of new cholinesterase inhibitors.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Schopnost nových karbamátů a karbazátů inhibovat hydrolýzu acetylcholinu byla testována stanovením indexu pI50, což je záporný dekadický logaritmus molární koncentrace ihibitoru snižující aktivitu (rychlost inhibice) o 50%. Získané výsledy byly porovnány s hodnotami platnými pro oficiální léčiva Alzheimerovy choroby ? Rivastigmin a Galantamin. (cs)
  • The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer´s disease treatment ? rivastigmine and galanthamine.
  • The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer´s disease treatment ? rivastigmine and galanthamine. (en)
Title
  • Half-inhibition concentrations of new cholinesterase inhibitors.
  • Half-inhibition concentrations of new cholinesterase inhibitors. (en)
  • Index pI50 nových inhibitorů cholinesteráz. (cs)
skos:prefLabel
  • Half-inhibition concentrations of new cholinesterase inhibitors.
  • Half-inhibition concentrations of new cholinesterase inhibitors. (en)
  • Index pI50 nových inhibitorů cholinesteráz. (cs)
skos:notation
  • RIV/00216275:25310/04:00001657!RIV08-MSM-25310___
http://linked.open.../vavai/riv/strany
  • 293-296
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 253100001)
http://linked.open...iv/cisloPeriodika
  • c
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 565898
http://linked.open...ai/riv/idVysledku
  • RIV/00216275:25310/04:00001657
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cholinesterases; inhibitors; index pI(50) (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [CF1C15F03FD2]
http://linked.open...i/riv/nazevZdroje
  • Z. Naturforsch.
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 59
http://linked.open...iv/tvurceVysledku
  • Ventura, Karel
  • Čegan, Alexander
  • Komers, Karel
  • Štěpánková, Šárka
  • Zdražilová, Pavla
http://linked.open...n/vavai/riv/zamer
issn
  • 0939-5075
number of pages
http://localhost/t...ganizacniJednotka
  • 25310
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