About: Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: A retrospective multicentre study     Goto   Sponge   NotDistinct   Permalink

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  • Background: About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptorimmunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggeststhat B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never beenexplored in a systematic manner or in a cohort of adequate size that would enable clinical conclusions to be drawn.Methods: For this retrospective, multicentre study, we analysed 8593 patients with CLL for whom immunogeneticdata were available. These patients were followed up in 15 academic institutions throughout Europe (in CzechRepublic, Denmark, France, Greece, Italy, Netherlands, Sweden, and the UK) and the USA, and data were collectedbetween June 1, 2012, and June 7, 2013.
  • Background: About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptorimmunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggeststhat B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never beenexplored in a systematic manner or in a cohort of adequate size that would enable clinical conclusions to be drawn.Methods: For this retrospective, multicentre study, we analysed 8593 patients with CLL for whom immunogeneticdata were available. These patients were followed up in 15 academic institutions throughout Europe (in CzechRepublic, Denmark, France, Greece, Italy, Netherlands, Sweden, and the UK) and the USA, and data were collectedbetween June 1, 2012, and June 7, 2013. (en)
Title
  • Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: A retrospective multicentre study
  • Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: A retrospective multicentre study (en)
skos:prefLabel
  • Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: A retrospective multicentre study
  • Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: A retrospective multicentre study (en)
skos:notation
  • RIV/00216224:14740/14:00079243!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED1.1.00/02.0068), P(EE2.3.20.0045)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 7521
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14740/14:00079243
http://linked.open...riv/jazykVysledku
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  • B lymphocyte receptor; CD38 antigen; adolescent; adult; aged; amino acid composition; antigen expression (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [BACB7F7FD3D5]
http://linked.open...i/riv/nazevZdroje
  • The Lancet. Haematology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 1
http://linked.open...iv/tvurceVysledku
  • Pospíšilová, Šárka
  • Skuhrová Francová, Hana
  • Plevová, Karla
  • Ghia, P.
  • Langerak, A. W.
  • Darzentas, Nikos
  • Minga, E.
  • Anagnostopoulos, A.
  • Baliakas, P.
  • Belessi, C.
  • Davis, Z.
  • Oscier, D.
  • Stamatopoulos, K.
  • Geisler, C. H.
  • Agathangelidis, A.
  • Davi, F.
  • Rosenquist, R.
  • Sutton, L. A.
  • Chiorazzi, N.
  • Mansouri, L.
  • Panagiotidis, P.
  • Tzenou, T.
  • Gardiner, A.
  • Angelis, L.
  • Boudjogra, M.
  • Catherwood, M.
  • Chatzouli, M.
  • Chu, C. C.
  • Facco, M.
  • Giudecelli, V.
  • Hadzidimitriou, A.
  • Jelínek, D. F.
  • Juliusson, G.
  • Lefranc, M. P.
  • Montillo, M.
  • Nguyen-Khac, F.
  • Nichelatti, M.
  • Pedersen, L. B.
  • Sandberg, Y.
  • Scarfó, L.
  • Shanafelt, T.
  • Smedby, K. E.
  • Trentin, L.
  • Tsanousa, A.
  • Veronese, S.
  • Vojdeman, F. J.
  • Yan, X. J.
  • van Lom, K.
issn
  • 2352-3026
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/S2352-3026(14)00005-2
http://localhost/t...ganizacniJednotka
  • 14740
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