About: Neutralizing antibodies can initiate genome release from human enterovirus 71

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About: Neutralizing antibodies can initiate genome release from human enterovirus 71 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.pnas.org/content/111/6/2134.full
Description	Antibodies were prepared by immunizing mice with empty, immature particles of human enterovirus 71 (EV71), a picornavirus that causes severe neurological disease in young children. The capsid structure of these empty particles is different from that of the mature virus and is similar to %22A%22 particles encountered when picornaviruses recognize a potential host cell before genome release. The monoclonal antibody E18, generated by this immunization, induced a conformational change when incubated at temperatures between 4 degrees C and 37 degrees C with mature virus, transforming infectious virions into A particles. The resultant loss of genome that was observed by cryo-EM and a fluorescent SYBR Green dye assay inactivated the virus, establishing the mechanism by which the virus is inactivated and demonstrating that the E18 antibody has potential as an anti-EV71 therapy. The antibody-mediated virus neutralization by the induction of genome release has not been previously demonstrated. Antibodies were prepared by immunizing mice with empty, immature particles of human enterovirus 71 (EV71), a picornavirus that causes severe neurological disease in young children. The capsid structure of these empty particles is different from that of the mature virus and is similar to %22A%22 particles encountered when picornaviruses recognize a potential host cell before genome release. The monoclonal antibody E18, generated by this immunization, induced a conformational change when incubated at temperatures between 4 degrees C and 37 degrees C with mature virus, transforming infectious virions into A particles. The resultant loss of genome that was observed by cryo-EM and a fluorescent SYBR Green dye assay inactivated the virus, establishing the mechanism by which the virus is inactivated and demonstrating that the E18 antibody has potential as an anti-EV71 therapy. The antibody-mediated virus neutralization by the induction of genome release has not been previously demonstrated. (en)
Title	Neutralizing antibodies can initiate genome release from human enterovirus 71 Neutralizing antibodies can initiate genome release from human enterovirus 71 (en)
skos:prefLabel	Neutralizing antibodies can initiate genome release from human enterovirus 71 Neutralizing antibodies can initiate genome release from human enterovirus 71 (en)
skos:notation	RIV/00216224:14740/14:00079179!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Plevka, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	32285
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00079179
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DECAY-ACCELERATING FACTOR; CELL ENTRY; CRYSTAL-STRUCTURE; POLIOVIRUS; RECEPTOR; INTERMEDIATE; PICORNAVIRUS; PARTICLE; VIRUS; TRANSITIONS (en)
http://linked.open.../riv/klicoveSlovo	RECEPTOR CRYSTAL-STRUCTURE PARTICLE VIRUS INTERMEDIATE CELL ENTRY DECAY-ACCELERATING FACTOR PICORNAVIRUS POLIOVIRUS TRANSITIONS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DC037A198CB7]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	111
http://linked.open...iv/tvurceVysledku	Plevka, Pavel Kuhn, R. J. Cardosa, J. Lim, P. Y. Perera, R. Rossmann, M. G. Suksatu, A.
http://linked.open...ain/vavai/riv/wos	000330999600029
issn	0027-8424
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1073/pnas.1320624111
http://localhost/t...ganizacniJednotka	14740

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