About: If the cap fits, wear it: an overview of telomeric structures over evolution

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About: If the cap fits, wear it: an overview of telomeric structures over evolution Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://download.springer.com/static/pdf/233/art%253A10.1007%252Fs00018-013-1469-z.pdf?auth66=1424688549_1693e66271e371331f99a2b7b64a52d7&ext=.pdf
Description	Genome organization into linear chromosomes likely represents an important evolutionary innovation that has permitted the development of the sexual life cycle; this process has consequently advanced nuclear expansion and increased complexity of eukaryotic genomes. Chromosome linearity, however, poses a major challenge to the internal cellular machinery. The need to efficiently recognize and repair DNA double-strand breaks that occur as a consequence of DNA damage presents a constant threat to native chromosome ends known as telomeres. In this review, we present a comparative survey of various solutions to the end protection problem, maintaining an emphasis on DNA structure. This begins with telomeric structures derived from a subset of prokaryotes, mitochondria, and viruses, and will progress into the typical telomere structure exhibited by higher organisms containing TTAGG-like tandem sequences. Genome organization into linear chromosomes likely represents an important evolutionary innovation that has permitted the development of the sexual life cycle; this process has consequently advanced nuclear expansion and increased complexity of eukaryotic genomes. Chromosome linearity, however, poses a major challenge to the internal cellular machinery. The need to efficiently recognize and repair DNA double-strand breaks that occur as a consequence of DNA damage presents a constant threat to native chromosome ends known as telomeres. In this review, we present a comparative survey of various solutions to the end protection problem, maintaining an emphasis on DNA structure. This begins with telomeric structures derived from a subset of prokaryotes, mitochondria, and viruses, and will progress into the typical telomere structure exhibited by higher organisms containing TTAGG-like tandem sequences. (en)
Title	If the cap fits, wear it: an overview of telomeric structures over evolution If the cap fits, wear it: an overview of telomeric structures over evolution (en)
skos:prefLabel	If the cap fits, wear it: an overview of telomeric structures over evolution If the cap fits, wear it: an overview of telomeric structures over evolution (en)
skos:notation	RIV/00216224:14740/14:00079175!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Říha, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	20415
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00079175
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Telomeres; Telomerase; Chromosomes; Genome evolution; DNA repair; Retrotransposons (en)
http://linked.open.../riv/klicoveSlovo	Chromosomes Telomeres DNA repair Telomerase Genome evolution Retrotransposons
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[1E7B822429B4]
http://linked.open...i/riv/nazevZdroje	Cellular and molecular life sciences
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	71
http://linked.open...iv/tvurceVysledku	Říha, Karel Derboven, E. Fulcher, N. Valuchova, S.
http://linked.open...ain/vavai/riv/wos	000330963900006
issn	1420-682X
number of pages	19 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00018-013-1469-z
http://localhost/t...ganizacniJednotka	14740

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